Publication Library
Leadership in Research and Publications
The leadership position of the division’s Assisted Reproductive Technologies (ART) program is demonstrated in the numerous published papers which provide continuous education to the reproductive endocrinology community in the US. Fellows have the opportunity to participate in all ongoing projects and to present and publish these studies.
- Gill P, Ata B, Arnanz A, et al. Does recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123 987 patients. Human reproduction. Published online 2024. doi:10.1093/humrep/deae040
- Genovese HG, McQueen DB. The prevalence of sporadic and recurrent pregnancy loss. Fertil Steril. 2023 Nov;120(5):934-936. doi: 10.1016/j.fertnstert.2023.08.954. Epub 2023 Aug 28. PMID: 37648145.
- Willson S, Molinaro T, The distribution of high and low-level mosaicism and maternal age: lessons and hesitations. F S Rep. 2023 Jun 15;4(3):252-253. doi: 10.1016/j.xfre.2023.06.002. PMID: 37719095; PMCID: PMC10504551
- Reig A, Garcia-Velasco JA, Seli E. Bologna vs. POSEIDON criteria as predictors of the likelihood of obtaining at least one euploid embryo in poor ovarian response: an analysis of 6,889 cycles. Fertil Steril. 2023 May 13:S0015-0282(23)00378-3. PMID: 37187313.
- Reig A, Franasiak JM. We know to err (meiotically) is human, but do paternal factors impact paternal aneuploidy? Fertil Steril. 2022 Aug;118(2):289-290. PMID: 35786308.
- Herlihy NS, Klimczak AM, Titus S, Scott C, Hanson BM, Kim JK, Seli E, Scott RT The role of endometrial staining for CD138 as a marker of chronic endometritis in predicting live birth. J Assist Reprod Genet. 2022 Feb;39(2):473-479. PMID: 35064433
- Klimczak AM, Herlihy NS, Scott CS, Hanson BM, Kim JG, Titus S, Seli E, Scott RT Jr. B-cell lymphoma 6 expression is not associated with live birth in a normal responder in vitro fertilization population. Fertil Steril. 2022 Feb;117(2):351-358.PMID: 34809978
- Franasiak JM, Alecsandru D, Forman EJ, Gemmell LC, Goldberg JM, Llarena N, Margolis C, Laven J, Shoenmakers S, Seli E. A review of the pathophysiology of recurrent implantation failure. Fertil Steril. 2021 Dec;116(6):1436-1448. PMID: 34674825
- Roberts LM, Molinaro TA. The ghost in the machine (learning). Fertil Steril. 2021 Nov;116(5):1236-1237 PMID: 3460226
- Herlihy NS, Franasiak JM. Lending clarity via specificity to the diagnosis of chronic endometritis. Fertil Steril. 2021 Sep;116(3):680-681. PMID: 34330425
- Margolis C, Werner M, Jalas C. Variant haplophasing by long-read sequencing: proof of concept in preimplantation genetic workup and an opportunity to distinguish balanced and normal embryos. Fertil Steril. 2021 Sep;116(3):668-669 PMID: 34330424
- Glatthorn HN, Hanson BM, Kim JG, Herlihy NS, Klimczak AM, Hong KH, Seli E, Scott RT Jr. Individual culture leads to decreased blastocyst formation but does not affect pregnancy outcomes in the setting of a single, vitrified-warmed euploid blastocyst transfer. J Assist Reprod Genet. 2021 Aug;38(8):2157-2164 PMID: 34086147
- Reig A, Herraiz S, Pellicer A, Seli E. Emerging follicular activation strategies to treat women with poor ovarian response and primary ovarian insufficiency. Curr Opin Obstet Gynecol 2021 Jun 1;33(3):241-248. PMID: 33896920
- Reig A, Franasiak JM. Fresh embryo transfer results in altered placental epigenetic regulation: a rationale for frozen embryo transfer. Fertil Steril. 2021 Dec;116(6):1481-1482 PMID: 34742555
- Kim JG, Patounakis G, Juneau CR, Morin SJ, Neal SA, Bergh PA, Seli E, Scott RT. The Appraisal of Body Content (ABC) Trial: increased male or female adiposity does not significantly impact IVF laboratory or clinical outcomes. Fertil Steril . 2021 Aug;116(2):444-452 PMID: 33581854
- Kim JG, Juneau CR, Patounakis G, Morin SJ, Neal SA, Seli E, Scott RT. The Appraisal of Body Content (ABC) Trial: obesity does not significantly impact gamete production in infertile men and women. J Assist Reprod Genet 2020 Nov;37(11):2733-2742. PMID: 32827101
- Murugappan G, Kim JG, Kort JD, Hanson BM, Neal SA, Tiegs AW, Osman EK, Scott RT, Lathi RB. Prognostic value of blastocyst grade after frozen euploid embryo transfer in patients with recurrent pregnancy loss. F&S Reports. 2020 Sept;1(2): 113-118. PMID: 33817669
- Klimczak AM, Franasiak JM. Peering into the window of receptivity: extracellular vesicles containing small noncoding RNAs as potential biomarkers. Fertil Steril. 2021 May;115(5):1185-1186. PMID: 33933177
- Klimczak AM, Seli EU, Scott RT Jr. Noninvasive prenatal testing in women undergoing in vitro fertilization with preimplantation genetic testing. Curr Opin Obstet Gynecol. 2021 Jun 1;33(3):184-187 PMID: 33797422
- Hanson BM, Kohn TP, Pastuszak AW, Scott RT Jr, Cheng PJ, Hotaling JM. Round spermatid injection into human oocytes: a systematic review and meta-analysis. Asian J Androl. 2021 Feb 9. doi: 10.4103/aja.aja_85_20. Online ahead of print. PMID: 33565426
- Hanson BM, Tao X, Zhan Y, Jenkins TG, Morin SJ, Scott RT Jr, Seli E. Young women with poor ovarian response exhibit epigenetic age acceleration based on evaluation of white blood cells using a DNA methylation-derived age prediction model. Hum Reprod. 2020 Nov 1;35(11):2579-2588. doi: 10.1093/humrep/deaa206. PMID: 33049778
- Hanson BM, Franasiak JM. Ovarian tissue cryopreservation is standard of care in prepubertal patients, but does it have to be? Fertil Steril. 2020 Aug;114(2):277-278. doi: 10.1016/j.fertnstert.2020.06.028. PMID: 32741466
- Hanson BM, Tao X, Hong KH, Comito CE, Pangasnan R, Seli E, Jalas C, Scott RT Jr. Noninvasive preimplantation genetic testing for aneuploidy exhibits high rates of deoxyribonucleic acid amplification failure and poor correlation with results obtained using trophectoderm biopsy. Fertil Steril. 2021 Jun;115(6):1461-1470. PMID: 33745720
- Alecsandru D, Klimczak AM, Garcia Velasco JA, Pirtea P, Franasiak JM. Immunologic causes and thrombophilia in recurrent pregnancy loss. Fertil Steril. 2021 Mar;115(3):561-566 PMID: 33610320
- Klimczak AM, Patel DP, Hotaling JM, Scott RT Jr. Role of the sperm, oocyte, and embryo in recurrent pregnancy loss. Fertil Steril. 2021 Mar;115(3):533-537. PMID: 33712098
- Klimczak AM, Franasiak JM. Vitamin D in human reproduction: some answers and many more questions. Fertil Steril. 2021 Mar;115(3):590-591. PMID: 33516577
- Hanson BM, Tao X, Zhan Y, Kim JG, Klimczak AM, Herlihy NS, Scott RT Jr, Seli E. Shorter telomere length of white blood cells is associated with higher rates of aneuploidy among infertile women undergoing in vitro fertilization. Fertil Steril. 2021 Apr;115(4):957-965. PMID: 33272640
- Klimczak AM, Reig A, Neal SA, Seli E, Scott RT Jr. Interpretation of noninvasive prenatal testing results following in vitro fertilization and preimplantation genetic testing for aneuploidy. Am J Obstet Gynecol MFM. 2020 Nov;2(4):100232. PMID: 33345935
- Tiegs AW, Tao X, Zhan Y, Whitehead C, Kim J, Hanson B, Osman E, Kim TJ, Patounakis G, Gutmann J, Castelbaum A, Seli E, Jalas C, Scott RT Jr. A multicenter, prospective, blinded, nonselection study evaluating the predictive value of an aneuploid diagnosis using a targeted next-generation sequencing-based preimplantation genetic testing for aneuploidy assay and impact of biopsy. Fertil Steril. 2021 Mar;115(3):627-637. PMID: 32863013
- Murugappan G, Kim JG, Kort JD, Hanson BM, Neal SA, Tiegs AW, Osman EK, Scott RT Jr., Lathi RB. Prognostic value of blastocyst grade predicts outcome after frozen euploid transfer in patients with recurrent pregnancy loss. F S Rep. 2020 Sep;1(2):113-118. PMID: 33817669
- Klimczak A, Seli E. Timing of frozen-thawed embryo transfers—does it really matter? Ann Transl Med. 2020 Jun;8(12):731. PMID: 32647656
- Hanson BM, Kim JG, Osman EK, Tiegs AW, Lathi RB, Cheng PJ, Scott RT, Franasiak JM. The impact of paternal age on embryology and pregnancy outcomes in the setting of a euploid single embryo transfer with ejaculated sperm: a retrospective cohort study. F S Rep. 2020 Sep 2;1(2):99-105. PMID: 34223225
- Hanson BM, Kaser DJ, Franasiak JM. Male infertility and the future of in vitro fertilization. Urol Clin North Am. 2020 May; 47(2):257-270. doi: 10.1016/j.ucl.2019.12.012. Epub 2020 Mar 9. PMID: 32272997
- Gross KX, Hanson BM, Hotaling JM. Round spermatid injection. Urol Clin North Am. 2020 May; 47(2):175-183. doi: 10.1016/j.ucl.2019.12.004. PMID: 32272989
- Morin SJ, Hanson BM, Juneau CR, Neal SA, Landis JN, Scott RT, Hotaling JM. A comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia. Asian J Androl. 2020 Mar-Apr; 22(2):222-226. doi: 10.4103/aja.aja_58_19. PMID: 31274475
- Tiegs Aw, Sun L, Scott RT Jr., Goodman LR. Comparison of pregnancy outcomes following intrauterine insemination in young women with decreased versus normal ovarian reserve. Fertil Steril. 2020 Apr;113(4):788-796. DOI:10.1016/j.fertnstert.2019.12.006 PMID: 32147173
- Juneau CR, Tiegs AW, Franasiak JM, Goodman LR, Whitehead C, Patounakis G, Scott RT Jr. Embryo’s Natural Motion (enMotion): a paired randomized controlled trial evaluating a dynamic embryo culture system. Fertil Steril. 2020 Mar;113(3):578-586 . DOI: 10.1016/j.fertnstert.2019.09.043 PMID: 32044089
- Tiegs AW, Tao X, Landis J, Zhan Y, Franasiak JM, Seli EU, Wells D, Fragouli E, Scott RT Jr. Sperm Mitochondrial DNA Copy Number Is Not a Predictor of Intracytoplasmic Sperm Injection (ICSI) Cycle Outcomes. Reprod Sci. 2020 Jun;27(6):1350-1356 DOI:10.1007/s43032-020-00163-0
- Tiegs AW, Sun L, Patounakis G, Scott RT Jr. Erratum. Worth the wait? Day 7 blastocysts have lower euploidy rates but similar sustained implantation rates as Day 5 and Day 6 blastocysts. Hum Reprod. 2019 Dec 1; 34(12):2559-2560.
- Tiegs AW, Landis J, Garrido N, Scott RT Jr, Hotaling JM. Total Motile Sperm Count Trend Over Time: Evaluation of Semen Analyses From 119,972 Men From Subfertile Couples. Urology. 2019 Oct; 132:109-116.
- Osman EK, Franasiak JM, Scott Jr. RT. Oocyte and Embryo Manipulation and Epigenetics. Semin Reprod Med. 2019 May; 36(7).
- Osman EK, Werner MD. Mosaic embryos present a challenging clinical decision. Fertil Steril. 2019 Jan; 111(1):52-53.
- Kim JG, Seli E. Mitochondrial DNA as a biomarker for IVF outcome. Reproduction 2019 epub.
- Hanson B, Hotaling J. Limitations and opportunities in male fertility databases. Transl Androl Urol. 2018 Jul; 7(3):S292-S302.
- Neal SA, Morin SJ, Franasiak JM, Goodman LR, Juneau CR, Forman EJ, Werner MD, Scott RT Jr. Preimplantation genetic testing for aneuploidy is cost-effective, shortens treatment time, and reduces the risk of failed embryo transfer and clinical miscarriage. Fertil Steril. 2018 Oct;110(5):896-904 https://www.ncbi.nlm.nih.gov/pubmed/30316435
- Morin SJ, Kaser DJ, Franasiak JM. The dilemma of aneuploidy screening on low responders. Curr Opin Obstet Gynecol. 2018 Jun;30(3):179-184. https://www.ncbi.nlm.nih.gov/pubmed/29697414
- Morin SJ, Scott RT Jr. Review Article, Knowledge gaps in male fertility: a reproductive endocrinology and infertility perspective. Trans Androl Urol 2018. doi: 10.21037/tau.2018.05.02
- Neal SA, Werner MD. The impact of contemporary preimplantation genetic screening and diagnosis on the detection of aneuploidy and inherited genetic diseases. Birth Defects Res. 2018;110(8):644-647. https://www.ncbi.nlm.nih.gov/pubmed/29714058
- Franasiak JM, Kaser DJ, Goodman LR, Patounakis G, Juneau CR, Morin SJ, Neal SA, Schlaff WS, Scott RT Jr. Characterization of reproductive endocrinology and infertility (REI) fellowship applicants: Guiding our mentees toward success. Fertility Research and Practice. 2017; Dec 8;3:18. https://www.ncbi.nlm.nih.gov/pubmed/29234501
- Juneau C, Kraus E, Werner M, Franasiak J, Morin S, Patounakis G, Molinaro T, de Ziegler D, Scott RT, Jr. Patients with endometriosis have aneuploidy rates equivalent to their age-matched peers in the in vitro fertilization population. Fertil Steril 2017;108(2):284-8. https://www.ncbi.nlm.nih.gov/pubmed/28651959
- Morin SJ. Oxygen tension in embryo culture: does a shift to 2% O2 in extended culture represent the most physiologic system? J Assist Reprod Genet 2017;34(3):309-14. https://link.springer.com/article/10.1007%2Fs10815-017-0880-z
- Morin SJ and Franasiak JM. Natural killer cells in reproduction: helpful, harmful, or misunderstood? Consider This: Fertility and Sterility Dialog. May 2017. https://www.fertstertdialog.com/users/16110-fertility-and-sterility/posts/16618-consider-this-morin
- Morin SJ, Frattarelli JL, Franasiak JM, Juneau CR, Scott RT Jr. Laser acupuncture before and after embryo transfer improves in vitro fertilization outcomes: a four-armed randomized controlled trial. Med Acupunct 2017;29(2):56-65. Selected by American Academy of Medical Acupuncture as part of Continuing Medical Education program. http://online.liebertpub.com/doi/abs/10.1089/acu.2017.1218
- Treff NR, Zhan Y, Tao X, Olcha M, Han M, Rajchel J, Morrison L, Morin SJ, Scott RT Jr. Levels of trophectoderm mitochondrial DNA do not predict the reproductive potential of sibling embryos. Hum Reprod 2017;32(4):954-62. https://www.ncbi.nlm.nih.gov/pubmed/28333210
- Morin SJ, Treff NR, Tao X, Scott RT III, Franasiak JM, Juneau CR, Maguire M, Scott RT Jr. Combination of uterine natural kill cell immunoglobulin receptor haplotype and trophoblastic HLA-C ligand influences risk of pregnancy loss: a retrospective cohort analysis of direct embryo genotyping data from euploid transfers. Fertil Steril 2017;107(3):677-83. https://www.ncbi.nlm.nih.gov/pubmed/28069185
- Neal SA, Franasiak JM, Forman EJ, Werner MD, Morin SJ, Tao X, Treff NR, Scott RT Jr. High relative deoxyribonucleic acid content of trophectoderm biopsy adversely affects pregnancy outcomes. Fertil Steril 2017;107(3):731-6. https://www.ncbi.nlm.nih.gov/pubmed/27939761
- Morin SJ, Scott RT Jr. Knowledge gaps in male infertility: an REI perspective. Trans Androl Urol 2017. In press.
- Morin SJ, Eccles J, Iturriaga A, Zimmerman R. Translocations, Inversions and Other Chromosome Rearrangements. Fertil Steril 2017;107(1):19-26. https://www.ncbi.nlm.nih.gov/pubmed/27793378
- Morin SJ, Schlaff W. Uterine fibroids and reproduction. Contemporary Ob/Gyn 2017;62(1):21-26. http://contemporaryobgyn.modernmedicine.com/contemporary-obgyn/news/optimal-approaches-fibroid-management
- Fox C, Morin S, Jeong JW, Scott RT Jr, Lessey BA. Fertil Steril 2016;105(4):873-84. https://www.ncbi.nlm.nih.gov/pubmed/26945096
- Treff NR, Thompson K, Rafizadeh M, Chow M, Morrison L, Tao X, Garnsey H, Reda CV, Metzgar TL, Neal S, Jalas C, Scott RT Jr, Forman EJ. SNP array- based analyses of unbalanced embryos as a reference to distinguish between balanced translocation carrier and normal blastocysts. J Assist Reprod Genet 2016, Aug;33(8):1115-9. https://www.ncbi.nlm.nih.gov/pubmed/27241531
- Forman E, Franasiak J, Patounakis G, Scott R. Why abandoning sustained implantation rate may be throwing the baby out with the bathwater. Human Reproduction. Accepted.
- Tobias T, Sharara F, Franasiak J, Heiser P, Pinckney-Clark E. Promoting the Use of Elective Single Embryo Transfer in Clinical Practice. Fertility Research and Practice. Accepted
- Franasiak J, Barnett R, Treff N, Scott RT. CYP1A1 3801T>C Polymorphism is not Associated with Variations in Total Motile Sperm or Fertilization Rates with ICSI. Fertil Steril. 2016 Apr 23 [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/27117375
- Olcha M, Franasiak J, Taylor D, Treff N, Scott RT. Genotypically determined ancestry across an infertile population: ovarian reserve and response parameters are not influenced by continental origin. Fertil Steril. 2016 Apr 14. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/27087402
- Juneau C, Franasiak J, Treff N. Challenges Facing Contemporary Preimplantation Genetic Screening. Curr Opin Obstet Gynecol. 2016 Jun;28(3):151-7. http://www.ncbi.nlm.nih.gov/pubmed/27042995
- Morin S, Tiegs A, Franasiak J, Juneau CR, Scott RT. FMR1 Gene CGG Repeat Number Variation within the Normal Range is not Predictive of Ovarian Response in IVF Cycles. Reprod Biomed Online. 2016 May;32(5):496-502. http://www.ncbi.nlm.nih.gov/pubmed/27013081
- Franasiak J, Wang X, Sun W, Molinaro T, Green K, Werner M, Juneau C, Morin S, Scott RT. Free Vitamin D Does not vary through the Proliferative Phase of the Menstrual Cycle. Endocrine. 2016 Apr 6. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/27052515
- Franasiak J, Ruiz-Alonso M, Scott RT, Simon, C. Both slowly developing embryos and a variable pace of luteal endometrial progression may conspire to prevent a normal birth in spite of a capable embryo. Fertil Steril. 2016 Apr;105(4):861-6. http://www.ncbi.nlm.nih.gov/pubmed/26940791
- Franasiak J, Ku L, Barnhart K. Curbside Consults in the Era of Social Media Connectivity and the creation of the SREI Forum . Fertil Steril 2016 Apr;105(4):885-6. http://www.ncbi.nlm.nih.gov/pubmed/26916178
- Werner M, Hong K, Franasiak J, Forman E, Reda C, Molinaro T, Upham K, Scott RT. Sequential versus Monophasic Media Impact Trial (SuMMIT): a paired randomized controlled trial comparing a sequential media system to a monophasic medium. Fertil Steril. 2016 May;105(5):1215-21. http://www.ncbi.nlm.nih.gov/pubmed/26826274
- Franasiak J, Olcha M, Bergh P, Hong K, Werner M, Forman E, Zimmerman R, Scott RT. Expanded Carrier Screening in an Infertile Population: How Often is Clinical Decision Making Affected? Genet Med. 2016 Mar 3. http://www.ncbi.nlm.nih.gov/pubmed/26938781
- Franasiak J, Werner MD, Juneau CR, Scott RT, Forman EJ. DHEA Supplementation Results in Supraphysiologic DHEA-S Serum Levels that Interfere with Progesterone Immunoassays, Resulting in Spurious Elevations that may Complicate Clinical Management in IVF. J Assist Reprod Genet. 2016 Mar;33(3):387-91. http://www.ncbi.nlm.nih.gov/pubmed/26758459
- Patounakis G, Bergh E, Forman E, Tao X, Lonczak A, Franasiak J, Treff N, Scott RT. Multiple thrombophilic single nucleotide polymorphisms lack a significant effect on outcomes in fresh IVF cycles: an analysis of 1717 patients. J Assist Reprod Genet. 2016 Jan;33(1):67-73. http://www.ncbi.nlm.nih.gov/pubmed/26545911
- Franasiak JM, Scott RT Jr. Introduction: Microbiome in human reproduction. Fertil Steril. 2015 Dec; 104(6):1341-3. http://www.ncbi.nlm.nih.gov/pubmed/26515381
- Franasiak JM, Scott RT Jr. Reproductive tract microbiome in assisted reproductive technologies. Fertil Steril 2015 Dec;104(6):1364-71. http://www.ncbi.nlm.nih.gov/pubmed/26597628
- Franasiak J, Werner M, Juneau C, Tao X, Landis J, Zhan Y, Treff N, Scott RT. Uterine Microbiome at the Time of Embryo Transfer: Next Generation Sequencing of the 16s Ribosomal Subunit. J Assist Reprod Genet. 2016 Jan;33(1):129-36. http://www.ncbi.nlm.nih.gov/pubmed/26547201
- Green K, Werner M, Franasiak J, Juneau CR, Hong KH, Scott RT. Investigating the optimal preconception TSH range for patients undergoing IVF when controlling for embryo quality. J Assist Reprod Genet. 2015 Oct; 32(10):1469-76. http://www.ncbi.nlm.nih.gov/pubmed/26280527
- Forman EJ, Franasiak JM, Scott RT Jr. Elevated progesterone levels in women on DHEA supplementation likely represent assay interference. J Assist Reprod Genet. 2015Apr; 32(4):661. http://www.ncbi.nlm.nih.gov/pubmed/25682116 – Free Article
- Werner MD, Scott RT, Treff NR 24-Chromosome PCR for aneuploidy screening. Curr Opin Obstet Gynecol. 2015 Jun;27(3):201-5. http://www.ncbi.nlm.nih.gov/pubmed/25699477
- Werner MD, Forman EJ, Hong KH, Franasiak JM, Bergh PA, Scott RT. Endometrial disruption does not improve implantation in patients who have failed the transfer of euploid blastocysts. J Assist Reprod Genet. 2015 Jan. 28. [Epub ahead of print]. http://www.ncbi.nlm.nih.gov/pubmed/25627023
- Franasiak JM, Yao X, Ashkinadze E, Rosen T, Scott RT Jr. Discordant embryonic aneuploidy testing and prenatal ultrasonography prompting androgen insensitivity syndrome diagnosis. Obstet Gynecol. 2015 Feb;125(2):383-6. http://www.ncbi.nlm.nih.gov/pubmed/25569013
- Werner MD, Leondires MP, Schoolcraft WB, Miller BT, Copperman AB, Robins ED, Arredondo F, Hickman TN, Gutmann J, Schillings WJ, Levy B, Taylor D, Treff NR, Scott RT Jr. Clinically recognizable error rate after the transfer of comprehensive chromosomal screened euploid embryos is low. Fertil Steril. 2014 Dec;102(6):1613-8. http://www.ncbi.nlm.nih.gov/pubmed/25439802 – Free Article
- Franasiak J, Molinaro T, Scott RT. Vitamin D levels do not impact IVF outcomes following the transfer of a euploid blastocyst. Reply to Letter. American Journal of Obstetrics and Gynecology. Nov 2014. http://www.ncbi.nlm.nih.gov/pubmed/25460841
- Franasiak J, Molinaro T, Scott RT. Vitamin D levels do not impact IVF outcomes following the transfer of a euploid blastocyst. Reply to Letter. American Journal of Obstetrics and Gynecology. Nov 2014. http://www.ncbi.nlm.nih.gov/pubmed/25460839
- Franasiak JM, Dondik Y, Molinaro TA, Hong KH, Forman EJ, Werner MD, Upham KM, Scott RT Jr. Blastocyst transfer is not associated with increased rates of monozygotic twins when controlling for embryo cohort quality. Fertil Steril. 2015 Jan;103(1):95-100. http://www.ncbi.nlm.nih.gov/pubmed/25455537
- Franasiak JM, Molinaro TA, Dubell EK, Scott KL, Ruiz AR, Forman EJ, Werner MD, Hong KH, Scott RT Jr. Vitamin D levels do not affect IVF outcomes following the transfer of euploid blastocysts. Am J Obstet Gynecol. 2014 Oct 11 [Epub ahead of print]. http://www.ncbi.nlm.nih.gov/pubmed/25265402
- Franasiak JM, Forman EJ, Hong KH, Werner MD, Upham KM, Treff NR, Scott RT Jr. Aneuploidy across individual chromosomes at the embryonic level in trophectoderm biopsies: changes with patient age and chromosome structure. J Assist Reprod Genet. 2014 Nov;31(11):1501-9. http://www.ncbi.nlm.nih.gov/pubmed/25241130
- Franasiak JM, Scott RT Jr. Embryonic aneuploidy: overcoming molecular genetics challenges improves outcomes and changes practice patterns. Trends Mol Med. 2014 Sep;20(9):499-508. http://www.ncbi.nlm.nih.gov/pubmed/25113799
- Werner MD, Forman EJ, Hong KH , Franasiak JM, Molinaro TA, Scott RT Jr. Defining the “sweet spot” for administered LH/FSH gonadotropin ratios during ovarian stimulation to protect against a clinically-significant late follicular rise in progesterone: An analysis of 10,280 first IVF cycles. Fertil Steril. 2014 Nov;102(5):1312-7. http://www.ncbi.nlm.nih.gov/pubmed/25150393
- Hong KH, Werner MD, Forman EJ, Upham KM, Winslow A, Kim TJ, Scott RT, JR. Endometrial infusion of human chorionic gonadotropin at the time of blastocyst embryo transfer does not impact clinical outcomes: a randomized double-blind, placebo-controlled trial. Fertil Steril. 2014 Dec;102(6):1591-5.e2. http://www.ncbi.nlm.nih.gov/pubmed/25234040
- Scott RT Jr, Franasiak JM, Forman EJ. Comprehensive chromosome screening with synchronous blastocyst transfer: time for a paradigm shift. Fertil Steril. 2014 Sep;102(3):660-1. http://www.ncbi.nlm.nih.gov/pubmed/25044086 – Free Article
- Forman EJ, Hong KH, Franasiak JM, Scott RT Jr. Obstetrical and neonatal outcomes from the BEST Trial: Single embryo transfer with aneuploidy screening improves outcomes after in vitro fertilization without compromising delivery rates. February 2014 Am J Obstet Gynecol 2014; 210: (157) e1-6. http://www.ncbi.nlm.nih.gov/pubmed/24145186 – Free Article
- Hong KH, Lee H, Forman EJ, Upham KM, Scott RT Jr. Examining the temperature of embryo culture in IVF: a randomized controlled trial comparing traditional core temperature (37C) to a more physiologic, cooler temperature (36C). Fertil Steril. 2014 Sep;102(3):767- 73. http://www.ncbi.nlm.nih.gov/pubmed/25044079
- Scott RT Jr, Hong KH, Werner MD, Forman EJ, Ruiz A, Cheng MC, Zhao T, Upham KM. Embryology training for Reproductive Endocrine fellows in the clinical human embryology laboratory. J Assist Reprod Genet. 2014 Apr;31(4):385-91. http://www.ncbi.nlm.nih.gov/pubmed/24557835 – Free PMC Article
- Franasiak JM, Forman EJ, Scott RT Jr. Reply of the authors. Fertil Steril. 2014 Jul;102(1):e4. http://www.ncbi.nlm.nih.gov/pubmed/24907911
- Franasiak J, Forman EJ, Hong KH, Werner M, Upham K, Treff NR, Scott RT. The Nature of Aneuploidy with Increasing Age of the Female Partner: A Review of 15,169 Trophectoderm Biopsies Undergoing Comprehensive Chromosomal Screening. Fertility and Sterility .2013 March; 101 (3): 656-663. http://www.ncbi.nlm.nih.gov/pubmed/24355045
- Forman EJ, Hong KH, Franasiak JM, Scott RT Jr. Obstetrical and neonatal outcomes from the BEST Trial: Single embryo transfer with aneuploidy screening improves outcomes after in vitro fertilization without compromising delivery rates. February 2014 Am J Obstet Gynecol 2014; 210: (157) e1-6. http://www.ncbi.nlm.nih.gov/pubmed/24145186
- Forman EJ, Hong KH, Ferry KM, Tao X, Taylor D, Levy B, Treff NR, Scott RT Jr. In vitro fertilization with single euploid blastocyst transfer: a randomized controlled trial. Fertil Steril 2013 Jul; 100(1):100-107. http://www.ncbi.nlm.nih.gov/pubmed/23548942 – http://www.fertstert.org/article/S0015-0282(13)00402-0/abstract
- Treff NR, Forman EJ, Scott RT Jr. Next-generation sequencing for preimplantation genetic diagnosis. Letter to the Editor. Fertil Steril 2013 May; 99(6):e17-e18
http://www.ncbi.nlm.nih.gov/pubmed/23481279 - Scott RT Jr., Ferry KM, Forman EJ, Hong KH, Scott KL, Taylor D, Tao X, Treff NR. Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases IVF implantation and delivery rates: a randomized controlled trial. Fertil Steril September 2013, 100 (3): 697-703. http://www.ncbi.nlm.nih.gov/pubmed/23731996
- Scott RT Jr., Ferry KM, Forman EJ, Zhao T, Treff NR. Cleavage stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial. Fertil Steril September 2013, 100 (3): 624-630. http://www.ncbi.nlm.nih.gov/pubmed/23773313
- Forman EJ, Upham KM, Cheng MZ, Zhao T, Hong KH, Treff NR, Scott RT Jr. Comprehensive chromosome screening alters traditional morphology-based embryo selection: a prospective study of 100 consecutive cycles of planned fresh euploid blastocyst transfer. Fertil Steril September 2013, 100 (3): 718-724. http://www.ncbi.nlm.nih.gov/pubmed/23725804 – https://www.thieme-connect.com/DOI/DOI?10.1055/s-0032-1311526
- Scott KL, Hong KH, Scott RT. Selecting the optimal time to perform biopsy for preimplantation genetics. Fertil Steril September 2013, 100 (3): 608-614. http://www.ncbi.nlm.nih.gov/pubmed/?term=Selecting+the+optimal+time+to+perform+biopsy+for+preimplantation+genetics
- Hong KH, Scott RT Jr. The Paradigm of Clinical IVF is shifting: The Time to Incorporate Validated Technologies and an Enhanced Understanding of Physiology is now. J Clin Embryology 2013:16(1):104-106.
- Forman EJ, Werner MD, Scott RT Jr. Extended culture and the risk of preterm delivery: Confounding by indication. Hum Reprod 2013 Jul;28(7):2021. http://www.ncbi.nlm.nih.gov/pubmed/23666754
- Treff NR, Forman EJ, Katz-Jaffe MG, Schoolcraft WB, Levy B, Scott RT, Jr. Incidental identification of balanced translocation carrier patients through comprehensive chromosome screening of IVF-derived blastocysts. J Assist Reprod Genet 2013; 30(6):787-91. http://www.ncbi.nlm.nih.gov/pubmed/23722938
- Forman EJ, Treff NR, Stevens JM, Garnsey HM, Katz-Jaffe MG, Scott RT Jr., Schoolcraft WB. Embryos whose polar bodies contain reciprocal chromosome aneuploidy are almost always euploid. Hum Reprod. 2013 Feb; 28(2):502-8. http://humrep.oxfordjournals.org/content/28/2/502.full.pdf+html?sid=0b7df5f6-c9ad-4664-8d2c-8b7a6df83c0d
- Forman EJ, Li X, Ferry KM, Scott K, Treff NR, Scott RT Jr. Oocyte vitrification does not increase the risk of embryonic aneuploidy or diminish the implantation potential of blastocysts created after intracytoplasmic sperm injection: a novel, paired randomized controlled trial using DNA fingerprinting. Fertil Steril. 2012 Sep;98(3):644-9.
An accompanying editorial by Ana Cobo, PhD, in the same issue praised this study as a “Watershed in ART.” http://www.ncbi.nlm.nih.gov/pubmed/22608316 - Forman EJ, Hong KH, Treff NR, Scott RT. Comprehensive chromosome screening and embryo selection: moving toward single euploid blastocyst transfer. Semin Reprod Med. 2012 Jun; 30(3):236-42. http://www.ncbi.nlm.nih.gov/pubmed/22585635
- Scott, RT, Treff, NR, Stevens J, Forman EJ, Hong KH, Katz-Jaffe MG, Schoolcraft WB. Delivery of a chromosomally normal child from an oocyte with reciprocal aneuploidy polar bodies. J Assist Reprod Genet. 2012 June; 29(6): 533–537. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370038/
- Forman EJ, Tao X, Ferry KM, Taylor D, Treff NR, Scott RT. Single embryo transfer with comprehensive chromosome screening results in improved ongoing pregnancy rates and decreased miscarriage rates. Hum Reprod. 2012 April; 27(4):1217-22. http://humrep.oxfordjournals.org/content/early/2012/02/16/humrep.des020.long
- Forman EJ, Treff NR, Scott RT Jr. Fertility after age 45: From natural conception to assisted reproductive technology and beyond. Maturitas 2011 Nov; 70(3):216-221. http://www.maturitas.org/article/S0378-5122(11)00237-4/pdf
✪ Top Prize Poster ASRM 2023
Gill P, Ata B, Arnanz A, Cimadomo D, Vaiarelli A, Fatemi H, Ubaldi F, Garcia-Velasco J, Seli E. Does recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123,987 patients. American Society for Reproductive Medicine Scientific Congress & Expo 2023. Top Poster Session. October 2023. New Orleans, LA
✪ 2023 ESHRE Clinical Science Award for Oral Presentation
“Multi-center randomized controlled trial of intraovarian injection of platelet rich plasma for women with poor ovarian response” was pre-selected for the Clinical Science Award for Oral Presentation at the next ESHRE meeting in Copenhagen (25 to 28 June 2023)
✪ ASRM 2021 Corporate Member Council In-Training Award
Klimczak AM, Herlihy NS, Hanson BM, Kim JG, Margolis CK, Roberts LM, Seli E, Scott RT Jr. Embryo vitrification with slush nitrogen yields similar pregnancy outcomes compared to liquid nitrogen: a randomized controlled trial. American Society for Reproductive Medicine Annual Meeting, Baltimore, Maryland October 2021
✪ PCRS Excellence-In-Training Award
Kim JG, Jalas C, Gill P, Walker Z, Vega C, Hanson BM, Herlihy NS, Klimczak AM, Margolis CK, Scott RT. Clinically recognized error rate after transfer of a single embryo screened by next-generation sequencing is 0.06%. Presented at the 69th Annual PCRS Meeting. May 6-8, 2021.
✪ PCRS 2021 Outstanding Paper Award 2nd place
Klimczak AM, Herlihy NS, Hanson BM, Kim JG, Margolis CK, Seli EU, Scott RT Jr. After Morphology Prioritization PGT-A Should Improve Implantation Rates by 10%. Presented at the 69th Annual PCRS Meeting. May 6-8, 2021.
✪ 3rd Place Outstanding Paper
Hanson, BM, Kim JG, Herlihy NS, Klimczak AK, Margolis CK, Roberts LP, Hong KH, Scott RT Jr. Individual culture leads to decreased blastulation but does not affect pregnancy outcomes in the setting of a single, vitrified-warmed euploid blastocyst transfer. Presented at the 69th Annual PCRS Meeting. May 6-8, 2021.
✪ SRI President’s Presenter’s Award
Tiegs AW, Tao X, Zhan Y, Jalas C, Whitehead C, Seli EU, Patounakis G, Gutmann J, Castelbaum A, Scott RT Jr. : A Multi-Center, Prospective, Blinded, Non-Selection Study Evaluating the Predictive Value (PV) Of an Aneuploid Preimplantation Genetic Testing for Aneuploidy (PGT-A) Diagnosis and Impact Of Biopsy. Accepted for presentation at the 67TH Annual Meeting of the Society for Reproductive Investigation (SRI). March 2020.
✪ ASRM Corporate Member Council In-training Travel Grant
Tiegs AW, Tao X, Whitehead C, Neal S, Osman E, Kim J, Hanson B, Seli E, Patounakis G, Gutman J, Castelbaum A, Scott RT Jr. Does preimplantation genetic testing for aneuploidy (PGT-A) harm embryos? No – A Multi-center, prospective, blinded, non-selection study evaluating the predictive value of an aneuploid diagnosis and impact of biopsy. American Society for Reproductive Medicine Annual Meeting. Philadelphia, PA. October 2019.
✪ ASRM Corporate Member Council In-training Travel Grant
Neal SA, Scott RT Jr., Goodman LR. Low endometrial volume is not associated with diminished live birth following transfer of a single thawed euploid blastocyst. American Society for Reproductive Medicine Annual Meeting. Philadelphia, PA. October 2019.
✪ 2019 Prize Paper Recipient
Hanson B, Tiegs A, Kim J, Osman E, Neal S, Scott RT. Assessing euploid status in day 5 or day 6 blastocysts among patients whose embryo cohorts undergo both normal and delayed blastulation. Abstract Oral Presentation. American Association of Bioanalysts Annual Meeting. New Orleans, LA. 2019.
✪ ASRM Corporate Member Council In-Training Travel Award
Neal SA, Goodman LR, Morin SJ, Werner MD, Gueye N, Tiegs AW, Pirtea P, Scott RT Jr. Only patients with obvious adenomyosis on three-dimensional ultrasound (3D US) are at increased risk of clinical loss following frozen embryo transfer. American Society for Reproductive Medicine Annual Meeting, Denver, CO October 2018.
✪ SMRU Traveling Scholars Program Award
Tiegs AW, Landis JN, Garrido N, Scott RT Jr., Hotaling JM. Total motile sperm count trend over time across two continents: evaluation of semen analyses from 119,972 infertile men. American Society for Reproductive Medicine Annual Meeting, Denver, CO October 2018.
✪ Pfizer President’s Presenter Award
Morin SJ, Tao X, Landis J, Zhan Y, Scott R, Seli E. . Epigenetic clock model of somatic aging accurately predicts chronological age when applied to white blood cells but not cumulus cells in reproductive age women. Society for Reproductive Investigation Annual Meeting, San Diego, CA. March 2018.
✪ Society for Male Reproduction and Urology Traveling Scholars Program
Scott Morin, M.D., O-11, “COMPARISON OF THE RELATIVE EFFICIENCY OF ICSI AND EXTENDED CULTURE WITH EPIDIDYMAL SPERM VERSUS TESTICULAR SPERM IN PATIENTS WITH OBSTRUCTIVE AZOOSPERMIA”
✪ SRBT Clinical Science Award
O-139, Tuesday, October 31, 2017, 11:00 am
THE LO2 TRIAL, PHASE I: A PAIRED RANDOMIZED CONTROLLED TRIAL (RCT) COMPARING BLASTULATION RATE IN ULTRA-LOW (2%) VS. LOW (5%) OXYGEN IN EXTENDED CULTURE (EC).
S. J. Morin, 1 D. J. Kaser,1 C. R. Juneau,1 S. A. Neal,1 K. Upham,2 X. Tao,3 Y. Zhan,3 R. T. Scott, Jr.1 ; 1 IVI/RMA, Thomas Jefferson University, Basking Ridge, NJ, 2 IVI/ RMA, Basking Ridge, NJ, 3 FEC, Basking Ridge, NJ
✪ Reproductive Immunology Special Interest Group Prize Paper
O-79, Monday, October 30, 2017, 11:00 am
CARES TRIAL (CELIAC DISEASE AND REPRODUCTIVE EFFECTS): CELIAC DISEASE IS NOT MORE COMMON IN PATIENTS UNDERGOING IVF AND OUTCOMES ARE NOT COMPROMISED IN AFFECTED PATIENTS.
C. R. Juneau, 1 D. Marin,1 K. Scott,2 S. J. Morin,1 S. A. Neal,1 J. Juneau,3 R. T. Scott, Jr.1 ; 1 IVI/RMA, Thomas Jefferson University, Basking Ridge, NJ, 2 IVI/RMA, Basking Ridge, NJ, 3 Robert Wood Johnson Medical School, Somerset, NJ
✪ ASRM Corporate Member Council In-Training Travel Awards
O-216, Wednesday, November 1, 2017, 12:15 pm
THE PERKS OF GOING TARGETED: SAMPLE CONTAMINATION, DNA FINGERPRINTING AND CHROMOSOMAL MOSAICISM ACCURATELY PREDICTED BY TARGETED NGS-BASED COMPREHENSIVE CHROMOSOME SCREENING.
D. Marin, 1,2 R. S. Zimmerman,3 C. Jalas,3 Y. Zhan,3 A. Lonczak,3 R. T. Scott, Jr.,1,2 N. Treff 1,2; 1 IVI/RMA, Basking Ridge, NJ, 2 Thomas Jefferson University, Philadelphia, PA, 3 Foundation for Embryonic Competence, Basking Ridge, NJ
✪ ASRM/NICHD/DUKE Clinical Research/ Reproductive Scientist Training (CREST) Program
Irene Souter, M.D., Vincent Memorial Obstetrics and Gynecology, Massachusetts General Hospital
Torie Plowden, M.D., Walter Reed National Military Medical Center
Dan Kaser, M.D., Reproductive Medicine Associates of New Jersey;
Jason Franasiak, M.D., Reproductive Medicine Associates of New Jersey, Thomas Jefferson University
Erica Dun, M.D., M.P.H., Yale University School of Medicine
Alexander Quaas, M.D., Ph.D., University of Oklahoma Health Sciences Center.
✪ 2016 SRBT Clinical Science Award
Marie D. Werner, MD, FACOG, TS (ABB) for the title “Targeted NGS Provides Accurate Predictions of Segmental (SEG) Aneuploidy and Prognosticates Reduced Reproductive Potential of the Human Blastocyst.” Presented at the 72nd Annual Meeting of the American Society of Reproductive Medicine, Salt Lake City, Utah October 15-19, 2016.
✪ 2016 SRBT Basic Science Award
Nathan Treff, Ph.D. Presented by the American Society for Reproductive Medicine for the title “COMPREHENSIVE CHROMOSOME SCREENING AND GENE EXPRESSION ANALYSIS FROM THE SAME BIOPSY.” Presented at the 72nd Annual Meeting of the American Society of Reproductive Medicine, Salt Lake City, Utah October 15-19, 2016.
✪ 2016 ASRM Corporate Member Council In-training Travel Grant
Morin SJ, Franasiak JM, Juneau CR, Tao X, Scott RT Jr. Trophectoderm biopsies with higher estimated cellularity increase risk of pregnancy loss and monozygotic twinning. Presented at the 72nd Annual Meeting of the American Society of Reproductive Medicine, Salt Lake City, Utah October 15-19, 2016.
✪ 2016 Prize Paper Recipient
Morin SJ, Franasiak JM, Juneau CR, Han M, Treff NR, Scott RT Jr. Uterine Natural Killer Cell Immunoglobulin Receptor (KIR) Genotypes and Trophoblastic Human Leukocyte Antigen C (HLA-C) Ligands Influence Risk of Pregnancy Loss: Data from Euploid Transfers. Oral Presentation. Presented at the American Association of Bioanalysts / College of Reproductive Biology meeting. Las Vegas, NV. 2016.
✪ 2016 Excellence In-Training Award
Juneau CR, Werner MD, Franasiak JM, Forman EJ, Hong KH, Scott RT, Jr. When Euploid Blastocysts are Selected for Embryo Transfer, Day Three Morphology Does Not Correlate with Implantation Rate. Oral Presentation. Pacific Coast Reproductive Society. Rancho Mirage, CA. 2016.
✪ 2015 ASRM Corporate Member Council In-training Travel Grant
Werner MD, Franasiak JM, Hong KH, Juneau CR, Tao X, Landis J, Upham KM, Treff NR, Scott RT , A prospective, blinded, non-selection study to determine the predictive value of ploidy results using a novel method of targeted amplification based next generation sequencing (NGS) for comprehensive chromosome screening (CCS). O-31 Presented at the 71st Annual Meeting of the American Society of Reproductive Medicine, Baltimore, MD October 17-21, 2015.
✪ 2015 Prize Paper Recipient
Franasiak J, Werner MD, Juneau CR, Scott RT. Use of Comprehensive Chromosome Screening as part of Routine Infertility Care is Associated with Decreased Transfer Order and Increased Elective Single Embryo Transfer. Abstract Oral Presentation. American Association of Bioanalysts Annual Meeting. Las Vegas, NV. 2015.
✪ 2015 Excellence in Training Award Recipient
Barnett R, Franasiak J, Treff N, Scott RT. CYP1A1 3801T>C Polymorphism is not Associated with Variations in Total Motile Sperm or Fertilization Rates with ICSI. Oral Presentation. Pacific Coast Reproductive Society Annual Meeting Rancho Mirage, CA. 2015.
✪ 2013 ASRM Corporate Member Council In-training Travel Award and In-Training Award for Research
Hong KH, Forman EJ, Werner MD, Hart CL, Winslow AD, Scott RT Jr. Endometrial infusion of human chorionic gonadotropin at the time of blastocyst embryo transfer does not improve clinical outcomes. O-400 Presented at the 69th Annual Meeting of the American Society for Reproductive Medicine, Boston, MA October 13-17, 2013.
Kathleen Hong, MD selected for a Corporate Member Council In-Training Travel Grant and In- Training Award for Research for the ASRM 2013 Meeting in Boston. Selection was based on the scientific merit of abstract O-400 and credentials.
✪ 2013 ASRM Poster Prize
Hong KH, Forman EJ, Prodoehl A, Upham KM, Treff NR, Scott RT Jr. Early times to cavitation are associated with a reduced prevalence of aneuploidy in embryos cultured to the blastocyst stage: a prospective blinded morphokinetic study. Presented at the 69th Annual Meeting of the American Society for Reproductive Medicine, Boston, MA October 13-17, 2013.
✪ 3rd Place Prize Paper
Forman EJ, Hong KH, Scott RT, Jr. Single embryo transfer with aneuploidy screening: same delivery rate, better obstetrical outcome. Presented at the 61st annual ACOG Annual Clinical Meeting, New Orleans, LA, May 8, 2013.
✪ 2012 ASRM Corporate Member Council In-training Travel Award
Forman EJ, Hong KH, Ferry KM, Tao X, Treff NR, Scott RT, Jr. Blastocyst euploid selective transfer (BEST): an RCT of comprehensive chromosome screening – single embryo transfer (CCS-SET) vs double embryo transfer (DET) – equivalent pregnancy rates, eliminates twins. Presented at the 68th Annual Meeting of the American Society for Reproductive Medicine, San Diego, CA, October 20-24, 2012.
Dr. Eric Forman selected for a Corporate Member Council In-Training Travel Grant for the ASRM 2012 Meeting in San Diego. Selection was based on the scientific merit of abstract O-161 and credentials.
✪ 3rd Place Prize Paper
E.J. Forman, K.H. Hong, R.T. Scott Jr. Single Embryo Transfer with Aneuploidy Screening: Same Delivery Rate, Better Obstetrical Outcome. Presented at 61st ACOG Annual Clinical Meeting. New Orleans, Louisiana, May 4-8, 2013.
✪ Prize Paper Candidate
N. R. Treff, K. M. Ferry, T. Zhao, J. Su, E. J. Forman, R. T. Scott Jr. Cleavage stage embryo biopsy significantly impairs embryonic reproductive potential while blastocyst biopsy does not: a novel paired analysis of cotransferred biopsied and non-biopsied sibling embryos. Presented at the 67th Annual Meeting of the American Society for Reproductive Medicine
Orlando, Florida October 15-19, 2011.
- Neal SA, Franasiak JM, Scott Jr. RT. Hematologic Disease in Implantation Failure. Recurrent Implantation Failure: Etiologies and Clinical Management.
- Hanson BM, Hotaling JM. Male factor infertility: genetic and epigenetic aspects. Human Reproductive Genetics: Emerging Technologies & Clinical Applications.
- Hanson B, Hotaling J. Metabolic Health: Inflammation and Men’s Health. Effects of Lifestyle on Men’s Health
- Morin SJ, Ata B, Seli E. Endocrine Causes of Recurrent Implantation Failure. Recurrent Implantation Failure. Springer. New York, NY. In press.
- Franasiak J, Scott RT. Embryo and Endometrial Synchrony. Recurrent Implantation Failure.
- Franasiak J, Scott RT. The Microbiome and Implantation Failure. Recurrent Implantation Failure.
- Franasiak J, Scott RT. Embryo Transfer and Post Transfer Care. American Board of Bioanalysts: Assisted Reproductive Technology.
- Franasiak J, Scott RT. Ovarian Stimulation. American Board of Bioanalysts: Assisted Reproductive Technology.
- Franasiak J, Scott RT. Preimplantation Genetic Diagnosis. American Board of Bioanalysts: Assisted Reproductive Technology.
- Franasiak J, Scott RT. Overview of PGD: Past, Present, & Future. Prenatal Diagnosis.
- Franasiak J, Scott RT. Demographics of Cancer in the Reproductive Age Female. Cancer and Infertility.
Presented at the American Society for Reproduction Medicine (ASRM) Annual Meeting, October 14 -18 , 2023, New Orleans, LA
- Gill P, Ata B, Arnanz A, Cimadomo D, Vaiarelli A, Fatemi H, Ubaldi F, Garcia-Velasco J, Seli E. Does recurrent implantation failure exist? Prevalence and outcomes of five consecutive euploid blastocyst transfers in 123,987 patients. American Society for Reproductive Medicine Scientific Congress & Expo 2023. Top Poster Session. October 2023. New Orleans, LA
- Gill P, Tao X, Whitehead C, Zhan Y, Werner M, Molinaro T, Jalas C, Capalbo A. Pregnancy outcomes of embryos diagnosed as putative mosaic (intermediate copy number) using preimplantation genetic testing for aneuploidy (PGT-A): a multisite blinded non-selection study. American Society for Reproductive Medicine Scientific Congress & Expo 2023. Oral Presentation. October 2023. New Orleans, LA
- Genovese HG, Willson S, Whitehead C, Zuckerman C, Seli E, Hotaling J, Cheng PJ. Sperm obtained via microsurgical testicular sperm extraction (mTESE) results in a similar blastulation rate and ongoing pregnancy rate as sperm obtained via testicular sperm aspiration (TESA)
- Willson S, Vera K, Genovese HG, Whitehead C, Molinaro T, Werner M. CHARACTERIZING SERUM HUMAN CHORIONIC GONADOTROPIN (HCG) RISE PARADIGM IN THE SETTING OF SINGLE, EUPLOID, FROZEN EMBRYO TRANSFER (FET): FINDINGS FROM 3,543 PREGNANCIES.
- Willson S, Genovese HG, Corirossi A, Hynniman K, Nunziato-Virga S, Caesar K, Umscheid E, Franasiak J. UTILIZATION OF PREIMPLANTATION GENETIC TESTING FOR MONOGENIC DISORDERS AMONGST INFERTILITY PATIENTS MEETING HEREDITARY CANCER SCREENING CRITERIA.
- Willson S, Genovese HG, Puchalt NG, Werner M, Seli E. IS OOCYTE DONATION ASSOCIATED WITH INCREASED IMPLANTATION AND PREGNANCY RATES IN ADVANCED REPRODUCTIVE AGE WOMEN UNDERGOING EUPLOID EMBRYO TRANSFER?
- Margolis CK, Garrido N, Roberts LM, Reig A, Gill P, Willson S, Genovese HG, Zuckerman C, Whitehead C, Bergh, P, Seli, E, Werner, M. MAPPING THE WAY TO SUCCESSFUL EUPLOID FROZEN EMBRYO TRANSFER: A PROSPECTIVE PILOT STUDY OF UTERINE SHEAR WAVE ELASTOGRAPHY (SWE)
- Margolis, CK, Barrett, F, Roberts, LM, Werner, M, Garrido, N, Seli E. AN ANALYSIS OF RECURRENT BIOCHEMICAL PREGNANCY LOSS AS IT COMPARES TO CLINICAL PREGNANCY LOSS IN EUPLOID VERSUS UNTESTED FROZEN EMBRYO TRANSFERS (FETS)
- Roberts LM, Herlihy N, Titus S, Garcia-Milian R, Margolis CK, Gill P, Reig A, Genovese HG, Willson S, Whitehead C, Werner M, Seli E. EXPLORING THE IMPACT OF INTRAOVARIAN PLATELET RICH PLASMA (PRP) INJECTION ON CUMULUS CELL RNA EXPRESSION
- Roberts, LM, Baker, A, Margolis, CK, Reig, A, Gill, P, Willson, S, Genovese, HG, Werner, M, Seli, E. FROM FRUSTRATION TO FERTILITY: A LOOK AT HOW PATIENTS’ ACTIVE ENGAGEMENT TRANSFORMS THEIR FERTILITY CARE JOURNEY
- Roberts, LM, Baker, A, Margolis CK, Reig A, Gill, P, Genovese, HG, Willson, S, Whitehead, C, Seli, E, Werner, M, Molinaro, T. WHEN EVERY DOSE COUNTS: COMMON MEDICATION ERRORS IN INFERTILITY CARE
- Reig A, Seli E. DEVELOPMENTAL ARREST RATE IN EMBRYOS OBTAINED FROM A COHORT OF RETRIEVED OOCYTES CORRELATES WITH AGE BUT NOT WITH ANEUPLOIDY RATE IN TROPHOECTODERM BIOPSIES: A STUDY OF 15,495 EMBRYOS
- Reig A, Herlihy N, Klimczak A, Gill P, Margolis CK, Roberts LM, Seli E, Scott RT. HYPERGLYCOSYLATED HUMAN CHORIONIC GONADOTROPIN (H-HCG) AS AN EARLY PREDICTOR OF BIOCHEMICAL AND CLINICAL PREGNANCY LOSS: A PROSPECTIVE ANALYSIS OF SINGLE, EUPLOID, FROZEN EMBRYO TRANSFERS.
- George, L, Reig, A, Werner, MD, Seli, E, Bergh, PA. Blastulation rate is associated with cumulative sustained implantation after in vitro fertilization (IVF) and euploid frozen embryo transfer (FET).
- Barrett F, Margolis CK, Roberts LM, Werner M, Garrido N, Seli E. AN INVESTIGATION INTO RISK FACTORS FOR BIOCHEMICAL AND CLINICAL PREGNANCY LOSS IN THE IVF POPULATION
Presented at the 71st Annual Meeting of the Pacific Coast Reproductive Society (PCRS) meeting, March 22-26, 2023, Indian Wells, CA
- Gill P, Whitehead C, Reig A, Margolis CK, Robert LM, Genovese HG, Willson S, Werner M. Letrozole is equivalent for endometrial preparation: an analysis of 2,972 single frozen euploid embryo transfers. Pacific Coast Reproductive Society 2023 Annual Meeting. Poster presentation. March 2023. Indian Wells, CA
- Gill P, Puchalt NG, Reig A, Margolis CK, Robert LM, Genovese H, Willson S, Molinaro TA, Hotaling J, Seli EU, Cheng P. Leukocytospermia does not negatively impact clinical pregnancy outcomes in women treated with intrauterine insemination: findings from 19,261 cycles. Pacific Coast Reproductive Society 2023 Annual Meeting. Poster presentation. March 2023. Indian Wells, CA
- Genovese HG, Yamada R, Willson S, Gill P, Reig A, Roberts LM, Margolis CK, Bergh P, Werner, M. Poor trophectoderm grade is associated with decreased live birth rate and increased risk of pregnancy loss after single frozen embryo transfer.
- Margolis, CK, Gallo, D, Roberts, LM, Gill, P, Reig, A, Willson, S, Genovese, HG, Whitehead, C, Seli E. SERUM HUMAN CHORIONIC GONADOTROPIN LEVELS DURING IVF STIMULATION AND THEIR RELATIONSHIP TO THE OUTCOME OF A SUBSEQUENT EUPLOID FROZEN EMBRYO TRANSFER
- Margolis, CK, Lobitz, G, Roberts, LM, Reig, A, Gill, P, Willson, S, Genovese, HG, Seli, E, Werner, M. AN INVESTIGATION INTO THE UTILITY OF DIPHENHYDRAMINE AFTER ONE FAILED EUPLOID FROZEN EMBRYO TRANSFER
- Roberts LM, Sachdev D, Margolis CK, Scarpetti K, Gill P, Reig A, Willson S, Genovese HG, Seli E, Werner M, Bergh P, Costantini-Ferrando M. EMBRYO TRANSFER TECHNIQUE MATTERS: AN EVALUATION OF 1,573 CASES
- Reig A, Gill P, Margolis CK, Roberts LM, Genovese HG, Willson S, Bergh P. EMBRYO NON-SURVIVAL TO WARMING IS ASSOCIATED WITH REPRODUCTIVE POTENTIAL OF THE ENTIRE COHORT
- Herlihy, N, Cakiroglu, Y, Whitehead, C, Reig, A, Klimczak, A, Scott, R, Tiras, B, Seli, E. A multi-center randomized controlled trial of intraovarian injection of platelet rich plasma for women with poor ovarian response.
- Genovese HN, Klimczak AM, Herlihy NS, Margolis CK, Roberts LM, Reig A, Gill P, Werner MD . Vitrified donor oocytes are associated with improved pregnancy outcomes compared with fresh donor oocytes in patients undergoing single frozen embryo transfer.
- Gill P, Zhan Y, Whitehead C, Tao X, Werner MD, Molinaro TA, Scott RT Jr., Jalas C. Embryos diagnosed as putative mosaic by the PGT seq PGT-a platform have a similar sustained implantation rate as those negative for putative mosaicism: a blinded non-selection study.
- Gill P, Whitehead C, Reig A, Margolis CK, Roberts LM, Herlihy NS, Klimczak AM, Seli EU. Best quality vs. sex selection – what takes priority for patients undergoing PGT-A? a historical analysis of embryo selection preferences.
- Esbert M, Reig A, Pangasnan, Ballesteros A, Seli EU. Oocyte maturation defect in women undergoing IVF: contributing factors and effects on mature sibling oocyte outcomes.
- Herlihy NS, Cakiroglu Y, Whitehead C, Klimczak AM, Scott RT Jr., Seli EU. The effect of intra-ovarian injection of platelet rich plasma on in vitro fertilization outcomes in young women with poor ovarian response: results from the PROVA (PRP for ovarian activation) trial.
- Klimzcak AM, Herlihy NS, Whitehead C, Margolis CK, Roberts LM, Gill P, Reig A, Seli EU, Scott RT Jr. Vitrification with slush nitrogen does not improve reproductive potential of frozen embryos: a randomized controlled trial.
- Margolis CK, Gallo D, Roberts LM, Herlihy NS, Klimczak AM, Reig A, Gill P, Whitehead C, Seli EU. A prospective study on the value of monitoring exogenous sourced serum human chorionic gonadotropin levels during IVF stimulation: lessons learned from 2,257 cycles.
- Reig A, Gill P, Herlihy NS, Klimczak AM, Margolis CK, Roberts LM, Seli EU. Women with poor ovarian response diagnosed based on poseidon or bologna criteria: how likely are they to have at least one euploid blastocyst for transfer?
- Gill P; Puchalt NG, Reig A, Margolis CK, Robert LM, Herlihy NS, Klimczak AM, Molinaro TA, Hotaling J, Seli EU, Cheng P. Leukocytospermia does not negatively impact embryologic or clinical outcomes in in-vitro fertilization cycles: findings from 5,435 cycles.
- Reig A, Gill P, Herlihy NS, Klimczak AM, Margolis CK, Roberts LM, Hong KH, Scott RT Jr. Fertilization rate is associated with the likelihood of being discharged pregnant, but not with embryo quality: analysis of 11,210 oocyte retrievals and 12,968 single frozen embryo transfers (FET).
- Roberts LM, Margolis CK, Reig A, Herlihy NS, Klimczak AM, Gill P, Drews MR, Seli EU, Molinaro TA, Social, clinical and laboratory predictors of patient engagement in women undergoing infertility treatment.
- Roberts LM, Margolis CK, Reig A, Herlihy NS, Klimczak AM, Gill P, Seli EU, Molinaro TA. Patients who choose in person VS telehealth first visit appointments: differences in baseline characteristics and engagement in care.
- Willson SF, Roberts LM, Margolis CK, Herlihy NS, Klimczak AM, Gill P, Reig A, Seli EU, Bergh PA, Werner MD. Reproductive outcomes after switching physicians in the setting of prior failed embryo transfer.
- Sachdev D, Margolis CK, Herlihy NS, Klimczak AM, Gill P, Drews MR, Seli EU, Molinaro TA. The embryo flash is not a meaningful predictor of euploid frozen embryo transfer outcomes.
- Kim JG, Jalas C, Gill P, Walker Z, Vega C, Hanson BM, Herlihy NS, Klimczak AM, Margolis CK, Scott RT. Clinically recognized error rate after transfer of a single embryo screened by next-generation sequencing is 0.06%.
- Klimczak AM, Herlihy NS, Hanson BM, Kim JG, Margolis CK, Seli EU, Scott RT Jr. After Morphology Prioritization PGT-A Should Improve Implantation Rates by 10%.
- Hanson, BM, Kim JG, Herlihy NS, Klimczak AK, Margolis CK, Roberts LP, Hong KH, Scott RT Jr. Individual culture leads to decreased blastulation but does not affect pregnancy outcomes in the setting of a single, vitrified-warmed euploid blastocyst transfer.
- Herlihy NS, Zhan Y, Klimczak AM, Hanson BM, Kim JK, Roberts LM, Margolis CK, Seli E, Scott RT Jr. Frozen in time: interval of cryopreservation does not affect reproductive potential of vitrified blastocysts.
- Klimczak AM, Herlihy NS, Hanson BM, Kim JG, Margolis CK, Roberts LM, Seli E, Scott RT Jr. Embryo vitrification with slush nitrogen yields similar pregnancy outcomes compared to liquid nitrogen: a randomized controlled trial.
- Fatunbi J, Margolis CK, Parks S, Roberts LM, Kim JG, Hanson BM, Klimczak AM, Herlihy NS, Seli E, Scott RT Jr. The influence of blastocyst morphological configuration on the occurrence of monozygotic twinning in single embryo transfer cycles.
- Reig A, Seli E, Scott RT Jr. Cryopreserved single embryo transfer is associated with improved neonatal outcomes in ivf-conceived newborns: A study of 8,671 singleton births.
- Hanson BM, Kim JG, Klimczak AM, Herlihy NS, Margolis CK, Roberts LM, Seli E, Scott RT Jr. Oocyte survival after vitrification using super-cooled slush nitrogen is similar to survival after vitrification with conventional liquid nitrogen: a randomized controlled trial.
- Hanson BM, Glatthorn HN, Kim JG, Klimczak AM, Herlihy NS, Margolis CK, Roberts LM, Seli E, Scott RT Jr. Pregnancy outcomes following a conversion from oral to vaginal estradiol due to endometrial hypoproliferation: an analysis of frozen euploid single embryo transfers.
- Kim JG, Jalas C, Zhan Y, Hanson BM, Herlihy NS, Klimczak AM, Margolis CK, Roberts LM, Hong KH, Seli E, Scott RT Jr. Neonatal outcomes are not impacted by a second trophectoderm biopsy.
- Kim JG, Comito C, Pangasnan R, Hanson BM, Klimczak AM, Herlihy NS, Hong KH, Seli E, Scott RT Jr. CONCO2 randomized controlled trial interim update: embryo culture in a continuous carbon dioxide setting does not negatively impact blastocyst formation rates
- Kim JG, Tao X, Cheng M, Zhao T, Steward A, Guo V, Zhan Y, Hanson BM, Scott RT Jr., Jalas C. The concordance rates of an initial trophectoderm biopsy with the rest of the embryo using PGTSEQ, a targeted next-generation sequencing platform.
- Herlihy NS, Tao X, Guo V, Zhan Y, Jalas C, Klimczak AM, Hanson BM, Kim JG, Roberts LM, Margolis CK, Seli E, Scott RT Jr., Franasiak JM. The microbiome of the reproductive tract does not impact reproductive outcomes.
- Klimczak AM, Herlihy NS, Kim JG, Hanson BM, Margolis CK, Roberts LM, Seli E, Scott RT Jr. Embryologists are more likely to choose euploid embryos for transfer: A prospective blinded non-selection trial.
- Gruber AT, Klimczak AM, Herlihy NS, Hanson BM, Kim JG, Margolis CK, Roberts LM, Seli E, Scott RT Jr. Obstetric and perinatal outcomes of natural cycle vs. artificial cycle frozen embryo transfers.
- Margolis CK, Roberts LM, Park S, Fatunbi J, Hanson BM, Kim JG, Klimczak AM, Herlihy NS, Seli E, Scott RT Jr. Cryo-synthetic frozen embryo transfer cycle outcomes with adjustment of progesterone in oil dosing the day prior to embryo transfer.
- Park S, Margolis CK, Fatunbi J, Roberts LM, Hanson BM, Kim JG, Herlihy NS, Klimczak AM, Seli E, Scott RT Jr. Single embryo transfer versus double embryo transfer and the subsequent risk of monozygotic twinning.
- Roberts LM, Le KN, Margolis CK, Herlihy NS, Klimczak AM, Kim JG, Hanson BM, Seli E, Scott RT Jr., Werner MD. Rates of Covid-19 infection in a fertility treatment population
- Le KN, Roberts LM, Margolis CK, Klimczak AM, Herlihy NS, Kim JG, Hanson BM, Seli E, Scott RT Jr., Werner MD. First trimester outcomes of patients seeking infertility care after covid-19 infection.
- Cheung J, Herlihy NS, Klimczak AM, Kim JG, Hanson BM, Margolis CK, Werner MD, Seli E, Scott RT Jr. Young eggs in an old basket – is there a maternal age limit for embryo transfer?
- Hanson B, Kim J, Tiegs A, Osman E, Hong K, Scott RT Jr. The relationship between age and rates of abnormal fertilization following intracytoplasmic sperm injection (ICSI).
- Tiegs AW, Tao X, Zhan Y, Jalas C, Whitehead C, Seli EU, Patounakis G, Gutmann J, Castelbaum A, Scott RT Jr. : A Multi-Center, Prospective, Blinded, Non-Selection Study Evaluating the Predictive Value (PV) Of an Aneuploid Preimplantation Genetic Testing for Aneuploidy (PGT-A) Diagnosis and Impact Of Biopsy. SRI President’s Presenter’s Award.
- Hanson BM, Tao X, Kim JG, Herlihy NS, Klimczak AM , Osman EK, Tiegs AW, Scott RT Jr. Noninvasive preimplantation genetic testing for aneuploidy exhibits high rates of DNA amplification failure and differs from trophectoderm biopsy results.
- Kim JG, Walker Z, Hanson BM, Osman EK, Tiegs AW, Klimczak AM, Herlihy NS, Scott RT Jr. Clinically recognized error rate after transfer of a single embryo screened by next-generation sequencing IS 0.13%.
- Klimczak AM, Herlihy NS, Kim JG, Hanson BM, Osman EK, Tiegs AW, Werner MD, Seli EU, Scott RT Jr. MPA use in donor cycles lessens financial burden of IVF medication costs.
- Herlihy NS, Kaser DJ, Klimczak AM, Hanson BM, Kim JG, Tiegs AW, Osman EK, Werner MD, Scott RT Jr. Extending the window of progesterone exposure in donor egg recipients.
- Osman EK, Tiegs AW, Kim JG, Hanson BM, Herlihy NS, Klimczak AM, Scott RT Jr. A critical threshold level of serum human chorionic gonadotropin reached during controlled ovarian stimulation is predictive of higher sustained implantation rates.
- Cheung J, Osman EK, Tiegs AW, Kim JG, Hanson BM, Herlihy NS, Klimczak AM, Scott RT Jr., Maguire M. Carriers of balanced translocations do not have decreased blastulation rates or sustained implantation rates compared to infertile controls.
- Walker Z, Osman EK, Sun L, Tiegs AW, Kim JG, Hanson BM, Herlihy NS, Klimczak AM, Scott RT Jr. The Impact of Mode of Delivery on Subsequent Single Embryo Transfer Cycles in Infertile Patients.
- Tiegs AW, Tao X, Zhan Y, Osman EK, Hanson BM, Kim JG, Herlihy NS, Klimczak AM, Jalas C, Scott RT Jr. Transfer outcomes of embryos with preimplantation genetic testing for aneuploidy (PGT-A) diagnoses of undetermined reproductive potential: results from a prospective, blinded, multi-center non-selection study.
- Hanson BM, Tao X, Zhan Y, Kim JG, Osman EK, Tiegs AW, Neal SA, Scott RT Jr., Seli E. Shorter telomere length of white blood cells is associated with higher rates of aneuploidy in women undergoing in vitro fertilization.
- Hanson BM, Kim JG, Osman EK, Tiegs AW, Neal SA, Werner MD, Scott RT Jr. The impact of ovarian response on clinical pregnancy and delivery rates in an oocyte donor population.
- Hanson BM, Tao X, Zhan Y, Jenkins TG, Scott RT Jr., Seli E. The relationship between chronologic age, ovarian response, and DNA methylation of white blood cells and cumulus cells among infertile women undergoing IVF.
- Hanson BM, Lathi RB, Kim JG, Osman EK, Tiegs AW, Neal SA, Franasiak JM, Scott RT Jr. Increased paternal age is associated with decreased blastulation and euploid rates but not pregnancy outcomes in the setting of a euploid single embryo transfer.
- Hanson BM, Kim JG, Osman EK, Tiegs AW, Neal SA, Lathi RB, Scott RT Jr., Franasiak JM. The impact of paternal age on reproductive outcomes in the setting of a euploid single embryo transfer achieved with surgically extracted sperm.
- Osman EK, Wang T, Yang M, Zhan Y, Juneau CR, Morin SJ, Seli E, Scott RT Jr., Franasiak JM. Varying levels of serum estradiol do not alter the timing of the early endometrial secretory transformation.
- Osman EK, Neal SA, Tiegs AW, Hanson BM, Kim JG, Franasiak JM, Scott RT Jr. Rates of embryonic mosaicism are consistent amongst embryologists performing or loading trophectoderm biopsies for preimplantation genetic testing for aneuploidy.
- Neal SA, Scott RT Jr., Goodman LR. Low endometrial volume is not associated with diminished live birth following the transfer of a single thawed euploid blastocyst. ASRM Corporate Member Council In-Training Travel Award.
- Neal SA, Scott RT Jr., Goodman LR. Pregnancy outcomes following hysteroscopic correction of T-shaped uteri.
- Neal SA, Tao X, Sun L, Tiegs AW, Osman EK, Hanson BM, Kim JG, Scott RT Jr., Franasiak JM. High concordance between vaginal and cervical microbiome assessments with increasing microbial diversity negatively impacts pregnancy outcomes following the transfer of a single euploid blastocyst.
- Neal SA, Morin SJ, Werner MD, Gueye NA, Pirtea P, Patounakis G, Scott RT Jr., Goodman LR. Three-dimensional ultrasound diagnosis of adenomyosis is not associated with diminished live birth following single thawed euploid blastocyst transfer: a prospective cohort study.
- Klimczak AM, Whitehead CR, Neal SA, Tiegs AW, Osman EK, Hanson BM, Kim JG, Werner MD, Franasiak JM, Scott RT Jr. Non-invasive prenatal testing has altered positive predictive value following the transfer of a euploid blastocyst.
- Kim JG, Murugappan G, Lathi RB, Kort JD, Hanson BM, Neal SA, Tiegs AW, Osman EK, Scott RT Jr. Preimplantation genetic testing for aneuploidy (PGT-A) reduces miscarriage and improves live birth rates in recurrent pregnancy loss patients.
- Kim JG, Hanson BM, Reig AR, Neal SA, Tiegs AW, Osman EK, Neal SA, Bergh PA, Seli E, Scott RT Jr. The impact of IVF on neonatal birth weight from 2000 to 2017: a dramatic reduction of low birth weight infants.
- Kim JG, Patounakis G, Juneau MD, Morin SJ, Neal SA, Tiegs AW, Osman EK, Hanson BM, Scott RT Jr. ABC Trial: body mass index and percentage body fat are not different in positive predictive value of miscarriage or preterm delivery in patients undergoing IVF.
- Tiegs AW, Tao X, Whitehead C, Neal SA, Osman EK, Kim JG, Hanson BM, Seli EU, Patounakis G, Gutmann J, Castlebaum A, Scott RT Jr. Does preimplantation genetic testing for aneuploidy (PGT-A) harm embryos? No — a multi-center, prospective, blinded, non-selection study evaluating the predictive value of an aneuploid diagnosis and impact of biopsy. ASRM Corporate Member Council In-Training Travel Award.
- Tiegs, AW, Neal SA, Osman EK, Kim JG, Hanson BM, Franasiak JM, Scott RT Jr, Goodman LR. Pregnancy outcomes following intrauterine insemination (IUI) in young women with decreased ovarian reserve.
- PRESENTED AT THE 23RD ANNUAL AAB CONFERENCE CRB SYMPOSIUM | NEW ORLEANS, LOUISIANA MAY 16TH TO 18TH, 2019
- Hanson B, Tiegs A, Kim J, Osman E, Neal S, Scott RT. Assessing euploid status in day 5 or day 6 blastocysts among patients whose embryo cohorts undergo both normal and delayed blastulation.
- Osman EK, Hong KH, Scott Jr. RT. A case of recurrent spontaneous parthenogenetic oocyte activation.
- PRESENTED AT THE AMERICAN UROLOGICAL ASSOCIATION (AUA) CHICAGO, ILLINOIS, MAY 3-6 , 2019
- Hanson BM, Kohn TP, Pastuszak AW, Scott RT Jr., Hotaling JM. Round spermatid injection into human oocytes: a systematic review and meta-analysis.
- Kim JG, Jalas C, Hanson BM, Tiegs AW, Osman EK, Neal SA, Scott RT Jr. Mapping of single nucleotide polymorphisms (SNPS) along a heterozgosity plot correlates with DNA copy number in comprehensive chromosome screening (CCS)
- Neal SA, Tiegs AW, Osman EK, Kim JG, Hanson BM, Werner MD, Scott RT Jr. When In vitro fertilization fails: is intrauterine insemination a reasonable treatment strategy?
- Hanson BM, Kim JG, Tiegs AW, Osman EK, Neal SA, Werner MD, Scott RT Jr. The effect of ovarian response on clinical pregnancy and delivery rates in an oocyte donor population.
- Tiegs AW, Sun L, Neal SA, Osman EK, Kim JG, Hanson BM, Scott RT Jr. Day 7 euploid blastocysts have reduced morphologic grades as completed with day 5 and 6 blastocysts but satisfactory sustained implantation
- Tiegs AW, Bauman B, Neal SA, Osman EK, Kim JG, Hanson BM, Scott RT Jr. Do variations exist in fertilization blastulation and sustained implantation rates by intracytoplasmic sperm injection (ICSI) operator?
- Osman EK, Neal SA, Tiegs AW, Kim JG, Hanson BM, Werner MD, Suns L, Franasiak JM Scott RT Jr. Embryonic aneuploidy rates in patients utilizing surgical sperm are equivalent to those utilizing ejaculated sperm for in vitro fertilization (IVF) cycles.
- Tiegs AW, Landis JN, Garrido N, Scott RT Jr., Hotaling JM. Total motile sperm count trend over time across two continents: evaluation of semen analyses from 119,972 infertile men. 2018 SMRU Traveling Scholars Program Award
- Neal SA, Goodman LR, Morin SJ, Werner MD, Gueye N, Tiegs AW, Pirtea P, Scott RT Jr. Only patients with obvious adenomyosis on three-dimensional ultrasound (3D US) are at increased risk of clinical loss following frozen embryo transfer. ASRM Corporate Member Council In-Training Travel Award.
- Kim JG, Morin SJ, Patounakis G, Juneau CR, Neal SA, Tiegs AW, Scott RT Jr. ABC Trial: Appraisal of body content, frozen embryo cycles are not impacted by the negative effects of obesity seen in fresh cycles.
- Morin SJ, Wang T, Tao X, Seli E. Ultra-low oxygen (O2) tension after day 3 of in vitro development does not alter blastocyst transcriptome: a comparison of 2% versus 5% O2 tension in extended culture.
- Morin SJ, Marin D, Landis JN, Scott RT Jr., Seli E. The telomere length of leukocytes and cumulus cells are not different between poor responders and good responders to controlled ovarian hyperstimulation for IVF.
- Tiegs AW, Tao X, Landis JN, Rajchel J, Bedard JL, Seli E, Wells D, Fragouli E, Scott RT Jr. Evaluation of sperm mitochondrial DNA copy number as a predictor of in vitro fertilization intracytoplasmic sperm injection (IVF/ICSI) cycle outcomes in a large infertile population.
- Neal SA, Goodman LR, Morin SJ, Werner MD, Gueye N, Tiegs AW, Pirtea P, Scott RT Jr. T-shaped uterine cavity morphology as assessed by three-dimensional ultrasound (3D US) is associated with lower sustained implantation rates and higher clinical loss rates following frozen embryo transfer.
- Osman E, Neal SA, Slowey M, Cook H, Schnorr J. The role of human chorionic gonadotropin (hCG) supplementation in oocyte donor ovarian stimulation.
- Mehta A, Hanson BM, Hawkins C, Stark L, Hotaling JM. A qualitative analysis of male partner needs in infertile couples.
- Parker PB, Morin SJ, Neal SA, Tiegs AW, Landis JN, Scott RT Jr., Werner MD. Inner cell mass and trophectoderm morphology impact the likelihood of achieving sustained implantation among expanded, euploid blastocysts.
- Reig A, Morin SJ, Goodman LR, Franasiak JM, Molinaro T, Scott RT Jr., Werner MD. Discordant follicle-stimulating hormone and anti0mullerian hormone and the prediction of euploid blastocyst yield.
- Dolitsky SN, Neal SA, Olcha M, Hong KH, Werner MD, Morin SJ, Tiegs AW, Sun L, Scott RT Jr. Initial serum human chorionic gonadotropin levels predict live birth outcomes following frozen embryo transfer with and without preimplantation genetic testing for aneuploidy.
- Tiegs AW, Sun L, Neal SA, Morin SJ, Werner MD, Scott RT Jr. Worth the wait? Findings from culturing embryos through day 7.
- Morin SJ, Tao X, Landis J, Zhan Y, Scott R, Seli E. . Epigenetic clock model of somatic aging accurately predicts chronological age when applied to white blood cells but not cumulus cells in reproductive-age women. Society for Reproductive Investigation Annual Meeting, San Diego, CA. March 2018. Pfizer President’s Presenter Award.
- Juneau CR, Marin D, Scott KL, Morin SJ, Neal SA, Scott RT Jr. CAREs TRIAL: Celiac and Reproductive Effects. Pacific Coast Reproductive Society. Indian Wells, CA. March 2017.
- Green KA, Franasiak JM, Juneau CR, Morin SJ, Patounakis G, Werner MD, Scott RT. Sperm DNA Fragmentation (SDF) on day of transvaginal oocyte retrieval (TVOR) is associated with semen parameters, though clinical outcomes correlation is unclear. Pacific Coast Reproductive Society. Indian Wells, CA. March 2017.
- Whitehead CV, Metzgar TL, Rana B, Lopes CF, Juneau CR, Morin SJ, Werner MD, Scott RT Jr. Is there a difference in sustained implantation rate (SIR) in patients who elect a gender preference versus those who select the best quality embryo for transfer when utilizing preimplantation genetic screening (PGS)? American Society for Reproductive Medicine Scientific Congress, San Antonio, TX. October 2017.
- Metzgar TL, Whitehead CV, Lopes CF, Rana B, Juneau CR, Morin SJ, Werner MD, Scott RT JR. Does Body Mass Index (BMI) impact the likelihood of a subject participating in a research study focused on body composition? American Society for Reproductive Medicine Scientific Congress, San Antonio, TX. October 2017.
- Kim JG, Juneau CR, Morin SJ, Neal SA, Franasiak JM, Patounakis G, Scott RT Jr. ABC Trial (Assessment of Body Content): Body composition in couples undergoing IVF predicts outcomes when Body Mass Index alone does not. American Society for Reproductive Medicine Scientific Congress, San Antonio, TX. October 2017.
- Franasiak JM, Hong KH, Werner MD, Juneau CR, Morin SJ, Neal SA, Molinaro TA, Scott RT Jr. Preimplantation genetic screening (PGS) in low responders shortens time to pregnancy: a randomized controlled trial. American Society for Reproductive Medicine Scientific Congress, San Antonio, TX. October 2017.
- Juneau CR, Franasiak JM, Morin SJ, Werner MD, Upham K, Scott RT Jr. EnMotion (Embryo’s Natural Motion): A paired randomized controlled trial demonstrating pregnancy rates are equivalent between static and dynamic culture systems. American Society for Reproductive Medicine Scientific Congress, San Antonio, TX. October 2017.
- Juneau CR, Marin D, Scott K, Morin SJ, Neal SA, Juneau J, Scott RT Jr. CARES Trial (Celiac Disease and Reproductive Effects): Celiac disease is not more common in patients undergoing IVF and outcomes are not compromised in affected patients. American Society for Reproductive Medicine Scientific Congress, San Antonio, TX. October 2017. Reproductive Immunology SIG Prize Paper.
- Morin SJ, Patounakis G, Juneau CR, Neal SA, Scott RT Jr., Seli E. Quantity versus quality: do patients with diminished ovarian reserve (DOR) and poor response to stimulation also exhibit poor blastulation and increased aneuploidy? American Society for Reproductive Medicine Annual Meeting, San Antonio, TX. October 2017.
- Morin SJ, Juneau CR, Neal SA, Landis JN, Scott RT, Jr., Hotaling JM. Comparison of the relative efficiency of ICSI and extended culture with epididymal sperm versus testicular sperm in patients with obstructive azoospermia. American Society for Reproductive Medicine Annual Meeting, San Antonio, TX. October 2017. Travelling Scholar Award, Society for Male Reproduction and Urology (SMRU).
- Goodman LR, Khan Z, Franasiak JM, Juneau CR, Morin SJ, Neal SA, Scott RT Jr. Current surgical experience and deficits in reproductive endocrinology and infertility training across fellowships in the United States. American Society for Reproductive Medicine Scientific Congress, San Antonio, TX. October 2017.
- Juneau CR, Marin D, Scott K, Morin SJ, Neal SA, Juneau J, Scott RT Jr. CARES Trial (Celiac Disease and Reproductive Effects): A gluten-free diet does not impact IVF outcomes. American Society for Reproductive Medicine Scientific Congress, San Antonio, TX. October 2017.
- Neal SA, Forman EJ, Juneau CR, Morin SJ, Molinaro T, Sun L, Zimmerman RS, Scott RT Jr. Rebiopsy and preimplantation genetic screening (PGS) reanalysis for embryos with an initial non-diagnostic result yield a euploid result in the majority of cases. American Society for Reproductive Medicine Scientific Congress, San Antonio, TX. October 2017.
- Neal SA, Forman EJ, Juneau CR, Morin SJ, Molinaro T, Sun L, Zimmerman RS, Scott RT Jr. Repeat biopsy of cryopreserved embryos for preimplantation genetic screening (PGS) reanalysis does not adversely impact reproductive potential. American Society for Reproductive Medicine Scientific Congress, San Antonio, TX. October 2017.
- Tiegs AW, Morin SJ, Forman EJ, Franasiak JM, Zimmerman RS, Zhan Y, Juneau CR, Neal SA, Treff N, Scott RT Jr. Only segmental or mosaic embryos available for transfer: a rare phenomenon in preimplantation genetic screening (PGS) cycles using targeted next-generation sequencing (NGS). American Society for Reproductive Medicine Scientific Congress, San Antonio, TX. October 2017.
- Morin SJ, Juneau CR, Neal SA, Scott RT Jr., Hotaling JM. Total motile sperm count is negatively correlated with fertilization rate but not blastulation, euploidy, or implantation in ICSI cycles. American Society for Reproductive Medicine Annual Meeting, San Antonio, TX. October 2017
- Morin SJ, Juneau CR, Neal SA, Scott RT Jr., Forman EJ. Elimination of a policy of empiric antibiotic therapy for male patients prior to collection for IVF results in no diminution in fertilization rate. American Society for Reproductive Medicine Annual Meeting, San Antonio, TX. October 2017.
- Dougherty MP, Morin SJ, Doherty L, Bohrer M, Leary S, Scott RT Jr. Surgical management of complete uterine/vaginal septum with duplication of the cervix. American Society for Reproductive Medicine Annual Meeting, San Antonio, TX. October 2017.
- Neal S, Landis J, Juneau C, Morin S, Scott RT. Pregnancy outcomes following conversion to vaginal estradiol for endometrial hypoproliferation in frozen embryo transfer cycles. Pacific Coast Reproductive Society Annual Meeting. Indian Wells, CA. March 2017.
- Chattopadhyay R, Juneau C, Landis J, Morin S, Neal S, Scott RT. Persistent fluid in the endometrial cavity that resolves after progesterone administration prior to transfer does not impact live birth rate. Pacific Coast Reproductive Society Annual Meeting. Indian Wells, CA. March 2017.
- Kim JG, Juneau CR, Landis J, Morin SJ, Neal SA, Scott RT. ABC Trial: Appraisal of Body Content. How percent body fat compares to body mass index in evaluating infertile couples. Pacific Coast Reproductive Society Annual Meeting. Indian Wells, CA. March 2017.
- Dougherty MP, Morin SJ, Juneau CR, Neal SA, Scott RT Jr. Fewer than 9 days of estrogen exposure prior to progesterone initiation results in lower pregnancy rates in programmed frozen embryo transfer cycles. Pacific Coast Reproductive Society Annual Meeting. Indian Wells, CA. March 2017.
- Hong KH, Forman EJ, Werner MD, Franasiak JM, Morin SJ, Whitehead CR, Treff NR, Scott RT Jr. Natural is not better: Gonadotropin stimulation does not increase aneuploidy or diminish implantation rates of euploid embryos.
- Juneau CR, Franasiak JM, Morin SJ, Werner MD, Upham K, Scott RT Jr. EnMotion: Embryo’s natural motion. Blastulation is not different between static and dynamic culture systems.
- Juneau CR, Morin SJ, Franasiak JM, Landis J, Molinaro T, Scott RT Jr. A ‘follicle-stimulating hormone boost’ Administered at the time of human chorionic gonadotropin trigger does not affect IVF cycle outcomes.
- Juneau CR, Franasiak JM, Morin SJ, Molinaro TA, Scott RT Jr. Obstetric outcomes following frozen transfer (FET) in patients with an endometrial thickness measuring <7mm.
- Juneau CJ, Franasiak JM, Morin SJ, Molinaro TA, Scott RT Jr., Maguire MF. Elevated anti-mullerian hormone (AMH) does not falsely predict ovarian response in patients with advanced-stage endometriosis.
- Morin SJ, Molinaro TA, Franasiak JM, Juneau CR, Scott RT Jr. Reduced developmental efficiency of vitrified donor oocytes (DOS) is explained by wide variation in fertilization success.
- Morin SJ, Franasiak JM, Juneau CR, Scott RT Jr. The live birth rate following embryo transfer is significantly influenced by the physician performing the transfer: data from 2707 euploid blastocyst transfers by 11 physicians.
- Morin SJ, Franasiak JM, Juneau CR, Werner MD, Johnson J, Pellicer A, Scott RT Jr. FMR1 premutation carriers are predisposed to poor ovarian response but exhibit no diminution in overall oocyte efficiency, blastulation rate, or increase in aneuploidy.
- Morin SJ, Franasiak JM, Juneau CR, Tao X, Scott RT Jr. Trophectoderm biopsies with higher estimated cellularity increase the risk of pregnancy loss and monozygotic twinning.
- Morin SJ, Han MM, Franasiak JM, Juneau CR, Treff N, Scott RT, Jr., Interaction of uterine natural killer cell immunoglobulin receptor (KIR) haplotype and trophoblastic HLA-C ligand influences risk of pregnancy loss: a retrospective analysis of direct embryo genotyping data.
- Franasiak JM, Tao X, Rajchel, Landis J, Zhan Y, Treff NR, Scott RT Jr. Assessment of the embryo transfer catheter microbiome after euploid blastocyst transfer is not predictive of sustained implantation.
- Neal S, Franasiak JM, Juneau CR, Morin SJ, Forman EJ, Werner MD, Treff NR, Scott RT Jr. Single embryo transfer (SET) following comprehensive chromosome screening (CCS) is more cost-effective than an unscreened sequential set.
- Werner MD, Goodrich D, Tao X, Zhan Y, Franasiak JM, Juneau CR, Scott RT Jr., Treff NT Targeted NGS provides accurate predictions of segmental aneuploidy and prognosticates reduced reproductive potential of the human blastocyst.
- Werner MD, Morin SJ, Molinaro TA, Franasiak JM, Upham KM, Scott RT Jr. Sequential (SEQ) VS. Monophasic (MONO) media impact trial (SUMMIT): Analysis of delivery outcomes amongst embryos cultured in different media formulations.
- Werner MD, Franasiak JM, Morin SJ, Forman EJ, Hong KH, Upham K, Scott RT Jr. A trinary scoring system generated be the EEVATM test’s time-lapse microscopy (TLM) software does not predict ploidy at the blastocyst stage or delivery of euploid embryos.
- Horne J, Franasiak JM, Juneau CR, Morin SJ, Forman EJ, Treff NR, Scott RT Jr. Paternal age does not impact aneuploidy rates as determined by comprehensive chromosome screening (CCS) in donor oocyte cycles.
- Treff NR, Zhan Y, Tao, X, Olcha M, Han M, Rajchel J, Morrison L, Morin SJ, Scott RT Jr. Levels of trophectoderm mitochondrial DNA do not predict the reproductive potential of human blastocysts.
- Morin S, Franasiak J, Juneau C, Han M, Treff N, Scott R. Uterine Natural Killer Cell Immunoglobulin Receptor (KIR) Genotypes and Trophoblastic Human Leukocyte Antigen C (HLA-C) Ligands Influence Risk of Pregnancy Loss: Data from Euploid Transfers. Prize Paper Award Recipient.
- Franasiak J, Tau X, Landis J, Zhan Y, Treff NT, Scott RT. Microbiome at the time of Embryo Transfer: Next Generation Sequencing of the 16S Ribosomal Subunit. Oral Presentation
- Juneau C, Werner M, Franasiak J, Green K, Lubitz S, Scott RT. Maintaining a TSH <2.5 mIU/L in the Pre-Conception Period does not Improve Oocyte Quality in Donor IVF. Electronic Poster Presentation
- Franasiak J, Wang, X, Sun W, Juneau CR, Morin S, Scott RT. Free Vitamin D does not vary through the Proliferative Phase of the Menstrual Cycle. Poster Presentation
- Juneau CR, Werner MD, Franasiak J, Scott RT. When euploid blastocysts are selected for embryo transfer, day three morphology does not correlate with implantation rate. Excellence in Training Award Recipient. http://www.fertstert.org/article/S0015-0282(15)02209-8/abstract
- Morin SJ, Werner MD, Franasiak J, Juneau CR, Scott RT. Prolonged time to first cytokinesis and the interval between the five cell stage and early cavitation are not associated with embryonic mosaicism. http://www.fertstert.org/article/S0015-0282(15)02215-3/abstract
- Horne J, Franasiak J, Olcha M, Juneau CR, Morin SJ, Bergh PA, Scott RT. Aneuploidy rate in donor oocyte cycles remain substantial but are lower when compared to general infertility population. http://www.fertstert.org/article/S0015-0282(15)02249-9/abstract
- Barnett R, Franasiak J, Scott RT, Forman EJ. Embryos derived from surgically-extracted sperm are not at an increased risk of aneuploidy. http://www.fertstert.org/article/S0015-0282(15)02232-3/abstract
- Franasiak J, Werner MD, Juneau CR, Tau X, Landis J, Zhan Y, Treff NT, Scott RT. Microbiome at the time of Embryo Transfer: Next Generation Sequencing of the 16S Ribosomal Subunit. http://www.fertstert.org/article/S0015-0282(15)00665-2/abstract
- Franasiak J, Werner MD, Juneau CR, Barnett B, Scott RT. Knowledge of Aneuploidy Status is Associated with Decreased Transfer Order and Increased Elective Single Embryo Transfer. (eSET). http://www.fertstert.org/article/S0015-0282(15)00790-6/abstract
- Green KA, Werner MD, Franasiak J, Tao X, Landis JN, Scott RT, Treff NT. Cumulus Cell Transcriptome Profiling using RNA-SEQ: A Paired Analysis of Euploid Sibling Blastocysts. http://www.fertstert.org/article/S0015-0282(15)00663-9/abstract
- Werner MD, Franasiak J, Hong KH, Juneau CR, Treff NT, Scott RT. A Prospective, Blinded, Non-selection Study to Determine the Clinical Utility of Next Generation Sequencing (NGS) for CCS. http://www.fertstert.org/article/S0015-0282(15)00542-7/abstract
- Juneau CR, Franasiak J, Werner MD, Forman EJ, Molinaro TA, Scott RT. Patients with Endometriosis do not have a Higher Rate of Aneuploidy. http://www.fertstert.org/article/S0015-0282(15)00715-3/abstract
- Franasiak J, Werner MD, Juneau CR Hong KH, Forman EJ, Scott RT. The selective power of extended culture: blastulation rates do not appreciably decrease until very late reproductive years http://www.fertstert.org/article/S0015-0282(15)01484-3/abstract
- Franasiak J, Werner MD, Juneau CR, Hong KH, Green KA, Scott RT. Incorporation of comprehensive chromosome screening (CCS) in IVF care is associated with faster resumption of care after failed embryo transfer. http://www.fertstert.org/article/S0015-0282(15)01598-8/abstract
- Olcha M, Tao X, Wang Y, Zhan Y, Franasiak J, Scott RT, Treff NR. A Mitochondrial D Loop Variant Associated with Reduced Risk of Embryonic Aneuploidy. http://www.fertstert.org/article/S0015-0282(15)01463-6/abstract
- Forman EJ, Treff NR, Franasiak J, Scott RT. Embryos from Female Carriers of Balanced Translocations do not have a Higher Risk of Whole-Chromosome Aneuploidy than their Age-Related Risk. http://www.fertstert.org/article/S0015-0282(15)01398-9/abstract
- Forman EJ, Werner MD, Franasiak J, Scott RT. Endometrial Disruption Does Not Result in a Reduced Endometrial Thickness or Alter the Proliferative Pattern in a Subsequent Frozen Embryo Transfer Cycle. http://www.fertstert.org/article/S0015-0282(15)01067-5/abstract
- Juneau CR, Werner MD, Franasiak J, Forman EJ, Hong KH, Molinaro TA, Scott RT. Does the Timing of Blastulation Prognosticate the Risk of Aneuploidy? http://www.fertstert.org/article/S0015-0282(15)01461-2/abstract
- Werner MD, Costantini-Ferrando MC, Franasiak J, Juneau CR, Reda C, Scott RT. One vs. Two: Patient Perspectives on Elective Single Embryo Transfer (eSET). http://www.fertstert.org/article/S0015-0282(15)01540-X/abstract
- Celestine C, Werner MD, Franasiak J, Juneau CR, Treff NR, Molinaro TA, Scott RT. Does Parental Origin of the Translocation Impact Rates of Abnormal Embryos? http://www.fertstert.org/article/S0015-0282(15)01232-7/abstract
- Werner MD, Hong KH, Franasiak J, Upham KM, Scott RT. Sequential vs. Monophasic Media Impact Trial: A Paired RCT Comparing Embryologic Parameters and Sustained Implantation Rates Amonst Sibling Zygotes. http://www.fertstert.org/article/S0015-0282(15)01490-9/abstract
- Werner MD, Franasiak J, Juneau CR, Green K, Upham KM, Scott RT. Computer-automated time-lapse microscopy (TLM) results enhance the opportunity to select embryos that blastulate within the window of endometrial receptivity. http://www.fertstert.org/article/S0015-0282(15)01472-7/abstract
- Werner MD, Green K, Franasiak J, Juneau CR, Upham KM, Scott RT. A revised binary scoring system generated by the Eeva™ test’s time-lapse microscopy (TLM) software may enhance selection at the cleavage stage. http://www.fertstert.org/article/S0015-0282(15)01471-5/abstract
- PRESENTED AT RUTGERS UNIVERSITY 8TH ANNUAL PIONEERS IN ENDOCRINOLOGY
NEW BRUNSWICK, NJ SEPTEMBER 2015 - Morin S, Tiegs A, Franasiak J, Juneau CR, Scott RT. FMR1 Gene CGG Repeat Number Variation within the Normal Range is not Predictive of Ovarian Response in IVF Cycles.
- Juneau C, Werner M, Franasiak J, Morin S, Green K, Lubitz S, Scott RT. Maintaining a TSH <2.5 mIU/L in the Pre-Conception Period does not Improve Oocyte Quality in Donor IVF.
- Franasiak J, Wang, X, Sun W, Juneau CR, Morin S, Scott RT. Free Vitamin D does not vary through the Proliferative Phase of the Menstrual Cycle.
- Franasiak J, Werner MD, Juneau CR, Scott RT, Treff NR. Differentiation of Trophectoderm in the Expanded Human Blastocyst.
- PRESENTED AT THE MIDWEST REPRODUCTIVE SOCIETY ANNUAL MEETING
CHICAGO, IL 2015 - Franasiak J, Werner MD, Juneau CR, Scott RT, Forman EJ. DHEA Supplementation Results in Supraphysiologic DHEA-S Serum Levels that Interfere with Progesterone Immunoassays, Resulting in Spurious Elevations that may Complicate Clinical Management in IVF.
- Juneau CR, Werner MD, Franasiak J, Green K, Lubitz S, Scott RT. Subclinical Hypothyroidism does not Impact Oocyte Quality Amongst Donors.
- Werner MD, Hong K, Franasiak J, Juneau CR, Treff N, Scott RT. The EEVA Test May Help Distinguish Uniformly Aneuploid Embryos from those that are Aneuploid and Mosaic.
- Green K, Werner MD, Franasiak J, Juneau CR, Scott RT. While a Second Trophectoderm Biopsy may Impact Sustained Implantation Rates after Euploid Single Embryo Transfer, Rates Remain High.
- Barnett R, Franasiak JM, Gabriele D, Gartmond TD, Treff NR, Scott RT Jr., CYP1A1 3801T>C Polymorphism is not associated with variations in total motile sperm or fertilization rates with ICSI. http://www.fertstert.org/article/S0015-0282(14)02504-7/abstract
- Olcha M, Franasiak JM, Taylor DT, Treff NR, Scott RT Jr. Markers of ovarian reserve do not differ amongst major ethnicities as determined by genotyping. http://www.fertstert.org/article/S0015-0282(14)02506-0/abstract
- Franasiak JM, Olcha M, Taylor DT, Treff NR, Scott RT Jr. Embryonic aneuploidy does not differ amongst major ethnicities as determined by genotyping. http://www.fertstert.org/article/S0015-0282(14)02456-X/abstract
- Franasiak JM, Horne J, Hong KH, Werner MD, Scott RT Jr. An embryo cohort which contains all aneuploid embryos is not indicative of future embryo cohort aneuploidy. http://www.fertstert.org/article/S0015-0282(14)00722-5/abstract
- Werner MD, Scott KL, Bohrer C, Gabrielle D, Tao X, Hong KH, Taylor D, Treff NR, Scott RT Jr. The accuracy of blastocoel fluid comprehensive chromosomal screening (CCS) is dependent on amplification yield and sequencing depth when using NextGen sequencing.
- Forman EJ, Franasiak JM, Scott KL, Dubell E, NG S, Scott RT Jr. DHEA supplementation results in supraphysiologic DHEA-S serum levels that interfere with progesterone (P) immunoassays resulting in spurious P elevations that may alter clinical management in IVF. http://www.fertstert.org/article/S0015-0282(14)01668-9/abstract
- Hong KH, Werner MD, Franasiak JM, Forman EJ, Upham KM, Treff NR, Scott RT Jr. Prolonged time to first cytokinesis and the interval between the five cell stage and early cavitation are associated with embryonic mosaicism. http://www.fertstert.org/article/S0015-0282(14)01333-8/abstract
- Hong KH, Werner MD, Franasiak JM, Forman EJ, Prodoehl A, Upham KM, Scott KL, Scott RT Jr. Embryologist interpretation if time-lapse imaging parameters at the blastocyst stage do not alter selection among transferred euploid blastocysts. http://www.fertstert.org/article/S0015-0282(14)01664-1/abstract
- Juneau CR, Hong KH, Werner MD, Franasiak JM, Upham KM, Scott RT Jr. Time-lapse imaging cleavage-stage parameters do not enhance selection among traditionally selected high-quality euploid blastocysts that implant. http://www.fertstert.org/article/S0015-0282(14)01663-X/abstract
- Franasiak JM, Olcha M, Bergh PA, Hong KH, Werner MD, Scott RT Jr. Expanded carrier screening in an infertile population: how often does it impact clinical decision making? http://www.fertstert.org/article/S0015-0282(14)00884-X/abstract
- Werner MD, Forman EJ, Hong KH, Franasiak JM, Neal SA, Scott RT Jr. Dual trigger with GnRH agonist (GnRHa) and varying doses of hCG increase the blastulation rate amongst high responders. http://www.fertstert.org/article/S0015-0282(14)01376-4/abstract
- Franasiak JM, Hong KH, Werner MD, Scott RT Jr. Embryonic metabolomics analysis utilizing neat infrared (NIR) spectroscopy to analyze embryos in the same cohort does not predict implantation rate: A prospective cohort study. http://www.fertstert.org/article/S0015-0282(14)01572-6/abstract
- Franasiak JM, Tao X, Lonczak A., Taylor DM, Treff NR, Hong KH, Werner MD, Scott RT III, Scott RT Jr. Characterizing the uterine microbiome: Next-generation sequencing of the V4 region of the 165 ribosomal gene. http://www.fertstert.org/article/S0015-0282(14)01091-7/abstract
- Werner MD, Hong KH, Franasiak JM, Upham KM, Scott RT Jr. A binary outcome predictor generated by time-lapse analysis software offers a limited selection advantage between blastocysts. http://www.fertstert.org/article/S0015-0282(14)01591-X/abstract
- Franasiak JM, Barnett R, Hong KH, Werner MD, Scott RT Jr. Proportion of aneuploidy does not impact live birth rate or pregnancy loss rate in patients with recurrent pregnancy loss (RPL) undergoing comprehensive chromosome screening. http://www.fertstert.org/article/S0015-0282(14)01212-6/abstract
- Franasiak JM, Juneau CR, Green K, Taylor DM, Hong KH, Werner MD, Scott RT Jr. Total motile sperm on semen analysis is not predictive of sex chromosome aneuploidy. http://www.fertstert.org/article/S0015-0282(14)01796-8/abstract
- Werner MD, Hong KH, Franasiak JM, Reda CV, Upham KM, Scott RT Jr. Sequential vs. monophasic media impact trial (Summit): A paired randomized controlled trial comparing blastulation rates or aneuploidy risk amongst sibling zygotes. http://www.fertstert.org/article/S0015-0282(14)01070-X/abstract
- Neal SA, Franasiak JM, Forman EJ, Werner MD, Taylor DM, Treff NR, Scott RT Jr. High cellularity of trophectoderm biopsy adversely affects pregnancy outcomes. http://www.fertstert.org/article/S0015-0282(14)01226-6/abstract
- Treff NR, Forman EJ, Bendarsky O, Neal SA, Scott RT Jr. Routinely distinguishing normal and balanced translocation carrier embryos using SNP arrays. http://www.fertstert.org/article/S0015-0282(14)01238-2/abstract
- Anderson K, Werner MD, Franasiak JM, Hong KH, Scott RT Jr. The impact of variations of TSH with the “low normal range” on euploid blastocyst implantation. http://www.fertstert.org/article/S0015-0282(14)00742-0/abstract
- PRESENTED AT THE MIDWEST REPRODUCTIVE SOCIETY ANNUAL MEETING
CHICAGO, IL JUNE 19-21, 2014 - Werner MD, Franasiak JM, Molinaro T, Dubell E, Scott K, Hong K, Forman E, Scott RT. Vitamin D Levels Do Not Impact IVF Outcomes Following the Transfer of Euploid Blastocysts.
- Franasiak JM, Forman EJ, Hong KH, Werner M, Treff NR, Scott RT. Aneuploidy Across Individual Chromosomes At The Embryonic Level In Trophectoderm Biopsies: Changes With Patient Age And Chromosome Structure.
- Hong KH, Forman EJ, Lee H, Upham KM, Treff NR, Scott RT Jr. Optimizing the temperature of embryo culture in IVF: a randomized controlled trial.
- Hong KH, Forman EJ, Werner MD, Hart CL, Winslow AD, Scott RT Jr. Endometrial infusion of human chorionic gonadotropin at the time of blastocyst embryo transfer does not improve clinical outcomes.
- PRESENTED AT THE 69TH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE
BOSTON, MA, OCTOBER 13-17, 2013 - Forman EJ, Hong KH, Werner MD, Singer SA, Benson MR, Scott RT Jr. Reducing the burden of art care: single blastocyst transfer after comprehensive chromosome screening provides equivalent delivery rates, eliminates twins, and lowers global health care costs. http://www.fertstert.org/article/S0015-0282(13)02588-0/abstract
- Forman EJ, Franasiak JM, Hong KH, Scott RT Jr. Late expanding euploid embryos that are cryopreserved with subsequent synchronous transfer have high sustained implantation rates similar to fresh normally blastulating euploid embryos. http://www.fertstert.org/article/S0015-0282(13)02495-3/abstract
- Forman EJ, Taylor D, Devkota B, Tao X., Treff NR, Scott RT Jr. Targeted deep sequencing of maternal cohesion genes as putative biomarkers for increased rick of embryonic aneuploidy. http://www.fertstert.org/article/S0015-0282(13)02623-X/abstract
- Hong KH, Forman EJ, Prodoehl A, Upham KM, Treff NR, Scott RT Jr. Early times to cavitation are associated with a reduced prevalence of aneuploidy in embryos cultured to the blastocyst stage: a prospective blinded morphokinetic study. http://www.fertstert.org/article/S0015-0282(13)01502-1/abstract
- Hong KH, Forman EJ, Werner MD, Hart CL, Winslow AD, Scott RT Jr. Endometrial infusion of human chorionic gonadotropin at the time of blastocyst embryo transfer does not improve clinical outcomes. http://www.fertstert.org/article/S0015-0282(13)02416-3/abstract
- Werner MD, Forman EJ, Hong KH, Kim J, Scott RT Jr. Extended embryo culture (blast): superior live birth rates (lbr) with small increased risk of adverse obstetrical outcomes as compared to cleavage-stage transfers. http://www.fertstert.org/article/S0015-0282(13)02356-X/abstract
- Forman EJ, Molinaro TA, Hong KH, Scott RT Jr. The use of an aromatase inhibitor to prevent elevated estrogen exposure in breast cancer fertility preservation patients results in a lower oocyte maturity rate despite larger follicles. http://www.fertstert.org/article/S0015-0282(13)02432-1/abstract
- Forman EJ, Salvaggio CN, Treff NR, Scott RT Jr. Polar Body (PB) based aneuploidy screening is significantly less predictive of the reproductive potential of embryos than embryo biopsy-based techniques. http://www.fertstert.org/article/S0015-0282(13)02132-8/abstract
- Scott KL, Hong KH, Werner MD, Forman EJ, Devkota B, Scott RT Jr. Patients with three or fewer embryos attain the highest delivery by culturing embryos to the blastocyst stage (blast) and assuring embryonic-endometrial synchrony rather than day 3 (d3) transfer. http://www.fertstert.org/article/S0015-0282(13)02412-6/abstract
- Treff NR, Tao X, Taylor D, Hong KH, Forman EJ, Scott RT J. Development and validation of next-generation sequencing. http://www.fertstert.org/article/S0015-0282(13)02734-9/abstract
- Forman EJ, Singer SA, Hong KH, Bergh PA, Scott RT Jr. Accrual of euploid blastocysts after comprehensive chromosome screening is a novel strategy to improve transfer outcomes and set expectations in poor prognosis patients. http://www.fertstert.org/article/S0015-0282(13)01104-7/abstract
- Forman EJ, Salvaggio CN, Katz-Jaffe M, Scott RT Jr., Treff NR, Schoolcraft WB. SNP Array intensity analysis of the 1st polar body (PB1) can reliably identify premature separation of sister chromatids (PSSC) in meiosis I (MI): A blinded validation study. http://www.fertstert.org/article/S0015-0282(13)02161-4/abstract
- Franasiak JM, Forman EJ, Hong KH, Werner MD, Upham KM, Scott RT Jr. Investigating the impact of the timing of blastulation on implantation: active management of embryo-endometrial synchrony increases implantation rates.
http://www.fertstert.org/article/S0015-0282(13)02489-8/abstract - Hong KH, Forman EJ, Lee H, Upham KM, Treff NR, Scott RT Jr. Optimizing the temperature of embryo culture in IVF: a randomized controlled trial. http://www.fertstert.org/article/S0015-0282(13)02521-1/abstract
- Werner MD, Hong KH, Forman EJ, Upham KM, Scott RT Jr. Parameters impacting the survival of vitrified blastocysts after warming. http://www.fertstert.org/article/S0015-0282(13)02188-2/abstract
- Werner MD, Forman EJ, Hong KH, Scott RT Jr. Re-defining the effect of exogenous LH activity in follicular stimulation: an analysis of 10,280 cycles validating the importance of exogenous LH activity in preventing a premature rise in progesterone. http://www.fertstert.org/article/S0015-0282(13)00953-9/abstract
- Werner MD, Forman EJ, Devkota B, Hong KH, Bergh PA, Scott RT Jr. Endometrial disruption does not improve endometrial receptivity in IVF: evaluation of clinical and sustained implantation rates following the transfer of euploid blastocysts.http://www.fertstert.org/article/S0015-0282(13)02696-4/abstract
- Werner MD, Forman EJ, Hong KH, Scott RT Jr. Optimizing cycle outcomes: the inclusion of exogenous LH activity is important in protecting against a late follicular rise in progesterone in low, normal, and high responders. http://www.fertstert.org/article/S0015-0282(13)01925-0/abstract
- Werner MD, Leondires M, Arredondo F, Hickman T, Schoolcraft W, Scott RT Jr. The clinical misdiagnosis rate with qPCR based comprehensive chromosomal screening (CCS) for embryonic aneuploidy is low and may commonly reflect mosaicism. http://www.fertstert.org/article/S0015-0282(13)02381-9/abstract
- Scott KL, Werner MD, Scott RT. Comprehensive chromosomal screening (CCS) dramatically reduces the age-related increase in 1st-trimester clinical losses but has only minimal impact on biochemical losses. http://www.fertstert.org/article/S0015-0282(13)00965-5/abstract
- Fedick A., Forman EJ, Eckert K., Thompson K., Taylor D., Scott RT Jr. Tagging SNP genotyping and targeted next-generation sequencing of the national gene to investigate the putative genetic association with azoospermia. http://www.fertstert.org/article/S0015-0282(13)02539-9/abstract
- Olcha M, Forman EJ, Hong KH, Werner MD, Ruiz A, Scott RT Jr. Aneuploidy rates within age groups do not differ within the typical therapeutic range of gonadotropin exposure. http://www.fertstert.org/article/S0015-0282(13)01911-0/abstract
- Pepe RJ, Forman J, Taylor D, Devokta B, Treff NR, Scott RT Jr. Creation of a DNA bank from patients with infertility: a powerful resource for advancing the biology of reproduction. http://www.fertstert.org/article/S0015-0282(13)01176-X/abstract
- PRESENTED AT THE 61ST ANNUAL ACOG ANNUAL CLINICAL MEETING, NEW ORLEANS, LA, MAY 8, 2013
- Forman EJ, Hong KH, Scott RT, Jr. Single embryo transfer with aneuploidy screening: same delivery rate, better obstetrical outcome.
- PRESENTED AT THE MIDWEST REPRODUCTIVE SYMPOSIUM 2013 CHICAGO, IL, JUNE 20-22, 2013
- Werner MD, Hong KH, Forman EJ, Scott RT. Trophectoderm biopsy does not increase neonatal morbidity as compared to non-biopsied embryos.
- PRESENTED AT THE 68TH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE
SAN DIEGO, CA, OCTOBER 20-24, 2012 - Forman EJ, Hong KH, Ferry KM, Tao X, Treff NR, Scott RT, Jr. Blastocyst euploid selective transfer (BEST): an RCT of comprehensive chromosome screening – single embryo transfer (CCS-SET) vs double embryo transfer (DET) – equivalent pregnancy rates, eliminates twins. http://www.fertstert.org/article/S0015-0282(12)00911-9/abstract
- Forman EJ, Hong KH, Ferry KM, Cheng MZ, Zhao T. Morphology plus ploidy: a prospective study comparing traditional morphology-based selection for single embryo transfer (SET) with comprehensive chromosome screening (CCS) results). http://www.fertstert.org/article/S0015-0282(12)00800-X/abstract
- Forman EJ, Su J, Taylor D, Devkota B, Treff NR, Scott RT, Jr. Oocyte vitrification does not result in a decrement in mitochondrial DNA (MTDNA) copy number in resulting embryos: a paired randomized controlled trial (RCT). http://www.fertstert.org/article/S0015-0282(12)01059-X/abstract
- Forman EJ, Ferry KM, Katz-Jaffe MG, Schoolcraft WB, Treff, NR, Scott RT, Jr. Trophectoderm (TE) biopsy, blastocyst vitrification, and simultaneous single gene disorder (SGD) and comprehensive chromosome screening (CCS) results in excellent ongoing pregnancy rates. http://www.fertstert.org/article/S0015-0282(12)01229-0/abstract
- Forman EJ, Stevens JM, Katz-Jaffe MG, Schoolcraft WB, Treff NR, Scott RT Jr. Embryos whose polar bodies had a reciprocal chromosomal abnormality are almost always euploid: a result of correction of premature separation of sister chromatids (PSSC).
http://www.fertstert.org/article/S0015-0282(12)00949-1/abstract - Hong KH, Taylor D, Forman EJ, Tao X, Treff NR, Scott RT, Jr. Development of a novel next-gen sequencing (NGS) methodology for accurate characterization of genome-wide mitochondrial heteroplasmy in human embryos. http://www.fertstert.org/article/S0015-0282(12)00942-9/abstract
- Hong KH, Forman EJ, Lee H, Ferry KM, Treff NR, Scott RT, Jr. Optimizing the temperature for embryo culture in IVF: A randomized controlled trial (RCT) comparing standard culture temperature of 37C to the reduced more physiologic temperature of 36C. http://www.fertstert.org/article/S0015-0282(12)01350-7/abstract
- Hong KH, Forman EJ, Ferry KM, Scott RT, Jr. GnRH antagonist (GnRHant) does not have a negative effect on endometrial receptivity: a comparison of outcomes of high-quality euploid blastocysts in fresh antagonist vs.agonist cycles.
http://www.fertstert.org/article/S0015-0282(12)01118-1/abstract - Hong KH, Werner MD Monozygotic twinning (MZT) rates increase with embryo cohort quality and are not directly related to cleavage (CL) stage or blastocyst (BL) stage transfer. http://www.fertstert.org/article/S0015-0282(12)01744-X/abstract
- Hong KH, Forman EJ, Devkota B, Bendarsky O, Treff, NR, Scott RT Jr. FMR1 gene CGG repeat number variation within the normal range is not predictive of embryonic aneuploidy rate (AR) in IVF.
http://www.fertstert.org/article/S0015-0282(12)01817-1/abstract - Hong KH, Molinaro TA, Forman EJ, Treff NR, Scott RT, Jr. Cohort aneuploidy rates are not predictive of sustained implantation rate of euploid blastocysts: give that blastocyst a chance.
http://www.fertstert.org/article/S0015-0282(12)01761-X/abstract - Werner MD, Forman EJ, Hong KH, Campos J, Treff NR, Scott R, Jr. Single nucleotide polymorphism (SNP) microarrays (MA) may be valuable in detecting small genomic imbalances and distinguishing balance from normal embryos for carriers of reciprocal translocations.
http://www.fertstert.org/article/S0015-0282(12)01217-4/abstract - Werner MD, Hong KH, Forman EJ, Treff NR, Scott RT, Jr. Body mass index (BMI) does not impact endometrial receptivity in fresh IVF cycles: evaluation of implantation rates (IR) and ongoing pregnancy rates (PR) following the transfer of euploid blastocysts.http://www.fertstert.org/article/S0015-0282(12)01774-8/abstract
- Werner MD, Hong KH, Forman EJ, Duffy L , Devkota B, Scott RT, Jr. Variation within the normal range in fragile X mental retardation 1 (FMR1) gene CGG repeat number is not predictive of ovarian responsiveness during IVF. http://www.fertstert.org/article/S0015-0282(12)01117-X/abstract
- Tao X, Scott RT III, Campos J, Forman EJ, Taylor D, Treff NR. Quantitative real-time (Q)PCR based embryonic DNA fingerprinting successfully distinguishes sibling human embryos: a practical tool for biomarker development.
http://www.fertstert.org/article/S0015-0282(12)01250-2/abstract - Garnsey H, Forman EJ, Ruiz A., Lonczak A, Treff NR, Scott RT Jr. Analysis of the earliest appearance of cell-free fetal DNA in material circulation.http://www.fertstert.org/article/S0015-0282(12)01140-5/abstract
- Scott RT, Jr., Forman EJ, Hong KH, Werner MD, Ruiz A, Ferry KM Embryology training for reproductive endocrinology (RE) fellows in the clinical human embryology Laboratory: Comprehensive training on actual clinical cases with excellent patient outcomes.http://www.fertstert.org/article/S0015-0282(12)01770-0/abstract
- Olcha M, Forman EJ, Hong KH, Ferry KM, Treff NR, Scott RT, Jr. Trophectoderm (TE) biopsy for aneuploidy screening results in lower initial HCG levels with altered predictive values: low initial levels still have high delivery rates and normal pregnancy outcomes. http://www.fertstert.org/article/S0015-0282(12)01146-6/abstract
- Shastri SM, Werner MD, Devkota B, Treff NR Scott RT Jr., Taylor D. Comparison of clinical outcomes between genetically similar groups of in vitro fertilization patients. http://www.fertstert.org/article/S0015-0282(12)00829-1/abstract
- PRESENTED AT THE 45TH ANNUAL MEETING OF THE SOCIETY FOR THE STUDY OF REPRODUCTION
STATE COLLEGE, PA, AUGUST 12-15, 2012 - Forman EJ, Ruiz A, Scott RT, Jr, Noll K, Sinko P, Chikindas M. The natural antimicrobial Subtilosin A demonstrates in vitro spermicidal activity: a controlled, blinded study.
- PRESENTED AT THE MIDWEST REPRODUCTIVE SYMPOSIUM 2012 CHICAGO, IL, MAY 18-19, 2012
- Forman EJ, Treff NR, Stevens J, Hong KH, Katz-Jaffe MG, Schoolcraft WB, Scott RT, Jr. Delivery of a chromosomally normal child from an oocyte with reciprocal aneuploid polar bodies.
- Hong KH, Forman EJ, Treff NR, Hensel KJ, Scott RT, Jr. Blastocyst transfer with comprehensive chromosome screening yields similar implantation and pregnancy rates across age groups in fresh IVF cycles.
- PRESENTED AT THE 67TH ANNUAL MEETING OF THE AMERICAN SOCIETY FOR REPRODUCTIVE MEDICINE
ORLANDO, FLORIDA OCTOBER 15-19, 2011 - Forman EJ, Treff NR, Tao X, Ferry KM, Taylor D, Scott RT Jr., Comprehensive chromosome screening (CCS) results in significantly higher pregnancy rates and lower loss rates from single embryo transfer (set) in a poor prognosis population.
http://www.fertstert.org/article/S0015-0282(11)01173-3/abstract - Forman EJ, Ferry KM, Benson MR, Campos J, Treff NR, Scott RT, Jr. Embryos derived from vitrified oocytes are not at an increased risk of aneuploidy and demonstrate excellent implantation rates: a paired, randomized controlled trial (RCT) in an infertile population.
http://www.fertstert.org/article/S0015-0282(11)01264-7/abstract - Forman EJ, Schultz PS, Rary L, Taylor D, Molinaro TA. Blastocyst morphology, but not age or maximum fsh, predicts implantation in the transfer of two euploid embryos.
http://www.fertstert.org/article/S0015-0282(11)01415-4/abstract - Forman EJ, Ferry KM, Gueye NA, Smith RD, Stevens J, Scott RT, Jr. Trophectoderm biopsy for single-gene disorder preimplantation genetic diagnosis (PGD) is significantly more reliable than day 3 blastomere biopsy.
http://www.fertstert.org/article/S0015-0282(11)01950-9/abstract - Hong KH, Forman EJ, Ruiz A., Scott RT, Jr. Inadequate luteinization: low serum progesterone after hCG trigger results in fewer mature oocytes per follicle and diminished pregnancy rates. http://www.fertstert.org/article/S0015-0282(11)02074-7/abstract
- Treff NR, Ferry KM, Zhao T, Su J, Forman EJ, Scott RT Jr. Cleavage stage embryo biopsy significantly impairs embryonic reproductive potential while blastocyst biopsy does not: a novel paired analysis of cotransferred biopsied and non-biopsied sibling embryos. http://www.fertstert.org/article/S0015-0282(11)01112-5/abstract
Presented at the 39th Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE), June 25-28, 2023, Copenhaguen, Denmark
Presented at the American Society for Reproduction Medicine (ASRM) Annual Meeting, October 22-26, 2022, Anaheim, CA